*AEK Athens 5-1 Kifisia FC
| 23.12.2021 | Kifisia FC | 1-1 | AEK Athens | |
| 01.12.2021 | AEK Athens | 4-0 | Kifisia FC | |
Agios Nikolaos 0-6 Anagennisi Karditsa *
| 22.12.2021 | Anagennisi Karditsa | 5-0 | Agios Nikolaos | |
| 02.12.2021 | Agios Nikolaos | 0-1 | Anagennisi Karditsa | |
Niki Volos 0-2 Panetolikos *
| 22.12.2021 | Panetolikos | 1-0 | Niki Volos | |
| 01.12.2021 | Niki Volos | 0-1 | Panetolikos | |
*Aris Salonica 5-1 OFI Creta
| 23.12.2021 | OFI Creta | 0-2 | Aris Salonica | |
| 01.12.2021 | Aris Salonica | 3-1 | OFI Creta | |
Levadiakos 3-4 Olympiakos Pireus *
| 22.12.2021 | Olympiakos Pireus | 2-0 | Levadiakos | |
| 01.12.2021 | Levadiakos | 3-2 | Olympiakos Pireus | |
*Panathinaikos 2-1 Volos NFC
| 23.12.2021 | Volos NFC | 0-0 | Panathinaikos | |
| 01.12.2021 | Panathinaikos | 2-1 | Volos NFC | |
AE Larisa 2-4 PAOK Salonica *
| 22.12.2021 | PAOK Salonica | 3-1 | AE Larisa | |
| 01.12.2021 | AE Larisa | 1-1 | PAOK Salonica | |