CD Irapuato 2-1 Club León
| 23.11.2008 | Club León | 1-1 | CD Irapuato | |
| 20.11.2008 | CD Irapuato | 1-0 | Club León | |
Mérida FC 1-4 Club Tijuana
| 23.11.2008 | Club Tijuana | 4-0 | Mérida FC | |
| 20.11.2008 | Mérida FC | 1-0 | Club Tijuana | |
Tigres B 2-2 Pumas Morelos
| 22.11.2008 | Pumas Morelos | 0-1 | Tigres B | |
| 20.11.2008 | Tigres B | 1-2 | Pumas Morelos | |
Correcaminos UAT 2-2 Querétaro FC
| 24.11.2008 | Querétaro FC | 1-0 | Correcaminos UAT | |
| 21.11.2008 | Correcaminos UAT | 2-1 | Querétaro FC | |