CF Monterrey 8-5 Guadalajara Chivas
| 18.05.2008 | Guadalajara Chivas | 4-4 | CF Monterrey | |
| 15.05.2008 | CF Monterrey | 4-1 | Guadalajara Chivas | |
Club Necaxa 2-3 Santos Laguna *
| 19.05.2008 | Santos Laguna | 1-1 | Club Necaxa | |
| 16.05.2008 | Club Necaxa | 1-2 | Santos Laguna | |
Deportivo Toluca 1-1 San Luis FC
| 18.05.2008 | San Luis FC | 0-0 | Deportivo Toluca | |
| 16.05.2008 | Deportivo Toluca | 1-1 | San Luis FC | |
Jaguares Chiapas 2-2 Cruz Azul *
| 18.05.2008 | Cruz Azul | 2-1 | Jaguares Chiapas | |
| 15.05.2008 | Jaguares Chiapas | 1-0 | Cruz Azul | |