*Cruz Azul 3-1 UNAM Pumas
| 01.12.2008 | UNAM Pumas | 1-3 | Cruz Azul | |
| 23.11.2008 | Cruz Azul | 0-0 | UNAM Pumas | |
*Santos Laguna 5-2 San Luis FC
| 30.11.2008 | San Luis FC | 1-2 | Santos Laguna | |
| 24.11.2008 | Santos Laguna | 3-1 | San Luis FC | |
Tigres UANL 2-2 Atlante FC *
| 30.11.2008 | Atlante FC | 1-1 | Tigres UANL | |
| 23.11.2008 | Tigres UANL | 1-1 | Atlante FC | |
UAG Tecos 0-2 Deportivo Toluca *
| 30.11.2008 | Deportivo Toluca | 2-0 | UAG Tecos | |
| 23.11.2008 | UAG Tecos | 0-0 | Deportivo Toluca | |