Club América 2-4 Deportivo Toluca
| 09.05.2010 | Deportivo Toluca | 2-0 | Club América | |
| 03.05.2010 | Club América | 2-2 | Deportivo Toluca | |
*Monarcas Morelia 5-2 Guadalajara Chivas
| 09.05.2010 | Guadalajara Chivas | 0-1 | Monarcas Morelia | |
| 02.05.2010 | Monarcas Morelia | 4-2 | Guadalajara Chivas | |
*Pachuca CF 3-1 CF Monterrey
| 09.05.2010 | CF Monterrey | 1-2 | Pachuca CF | |
| 02.05.2010 | Pachuca CF | 1-0 | CF Monterrey | |
*Santos Laguna 2-1 UNAM Pumas
| 10.05.2010 | UNAM Pumas | 1-0 | Santos Laguna | |
| 03.05.2010 | Santos Laguna | 2-0 | UNAM Pumas | |