Jaguares Chiapas 1-2 Santos Laguna *
| 22.11.2010 | Santos Laguna | 1-0 | Jaguares Chiapas | |
| 19.11.2010 | Jaguares Chiapas | 1-1 | Santos Laguna | |
Pachuca CF 4-4 CF Monterrey *
| 21.11.2010 | CF Monterrey | 3-3 | Pachuca CF | |
| 19.11.2010 | Pachuca CF | 1-1 | CF Monterrey | |
San Luis FC 1-4 Club América *
| 21.11.2010 | Club América | 4-1 | San Luis FC | |
| 18.11.2010 | San Luis FC | 0-0 | Club América | |
*UNAM Pumas 3-2 Cruz Azul
| 21.11.2010 | Cruz Azul | 0-2 | UNAM Pumas | |
| 18.11.2010 | UNAM Pumas | 1-2 | Cruz Azul | |