Guadalajara Chivas 1-2 Club América *
| 16.05.2016 | Club América | 2-1 | Guadalajara Chivas | |
| 13.05.2016 | Guadalajara Chivas | 0-0 | Club América | |
Monarcas Morelia 2-5 Club León *
| 15.05.2016 | Club León | 4-1 | Monarcas Morelia | |
| 12.05.2016 | Monarcas Morelia | 1-1 | Club León | |
Santos Laguna 3-4 Pachuca CF *
| 16.05.2016 | Pachuca CF | 3-2 | Santos Laguna | |
| 13.05.2016 | Santos Laguna | 1-1 | Pachuca CF | |
Tigres UANL 3-4 CF Monterrey *
| 15.05.2016 | CF Monterrey | 1-2 | Tigres UANL | |
| 12.05.2016 | Tigres UANL | 1-3 | CF Monterrey | |