*Santos Laguna 3-2 CF Monterrey
| 17.05.2021 | CF Monterrey | 1-1 | Santos Laguna | |
| 14.05.2021 | Santos Laguna | 2-1 | CF Monterrey | |
*Pachuca CF 5-5 Club América
| 17.05.2021 | Club América | 4-2 | Pachuca CF | |
| 14.05.2021 | Pachuca CF | 3-1 | Club América | |
Club Atlas 1-1 Club Puebla *
| 16.05.2021 | Club Puebla | 1-0 | Club Atlas | |
| 13.05.2021 | Club Atlas | 1-0 | Club Puebla | |
Deportivo Toluca 3-4 Cruz Azul *
| 16.05.2021 | Cruz Azul | 3-1 | Deportivo Toluca | |
| 13.05.2021 | Deportivo Toluca | 2-1 | Cruz Azul | |