Orihuela CF 0-1 Atlético Madrid *
| 12.11.2008 | Atlético Madrid | 0-0 | Orihuela CF | |
| 29.10.2008 | Orihuela CF | 0-1 | Atlético Madrid | |
Getafe CF 0-1 CA Osasuna
| 13.11.2008 | CA Osasuna | 1-0 | Getafe CF | |
| 29.10.2008 | Getafe CF | 0-0 | CA Osasuna | |
CD Numancia 0-3 Sporting Gijón *
| 12.11.2008 | Sporting Gijón | 2-0 | CD Numancia | |
| 29.10.2008 | CD Numancia | 0-1 | Sporting Gijón | |
Club Portugalete 1-7 Valencia CF *
| 12.11.2008 | Valencia CF | 3-0 | Club Portugalete | |
| 29.10.2008 | Club Portugalete | 1-4 | Valencia CF | |
Elche CF 0-4 Deportivo La Coruña *
| 12.11.2008 | Deportivo La Coruña | 2-0 | Elche CF | |
| 29.10.2008 | Elche CF | 0-2 | Deportivo La Coruña | |
Benidorm CF* 0-2 FC Barcelona *
| 12.11.2008 | FC Barcelona | 1-0 | Benidorm CF* | |
| 28.10.2008 | Benidorm CF* | 0-1 | FC Barcelona | |
Hércules CF 3-7 Real Valladolid *
| 12.11.2008 | Real Valladolid | 2-2 | Hércules CF | |
| 29.10.2008 | Hércules CF | 1-5 | Real Valladolid | |
Real Murcia 2-3 Racing Santander *
| 12.11.2008 | Racing Santander | 2-0 | Real Murcia | |
| 29.10.2008 | Real Murcia | 2-1 | Racing Santander | |
Rayo Vallecano 1-5 UD Almería *
| 12.11.2008 | UD Almería | 3-0 | Rayo Vallecano | |
| 29.10.2008 | Rayo Vallecano | 1-2 | UD Almería | |
Celta de Vigo 2-5 RCD Espanyol *
| 12.11.2008 | RCD Espanyol | 3-0 | Celta de Vigo | |
| 29.10.2008 | Celta de Vigo | 2-2 | RCD Espanyol | |
CD Castellón 0-4 Real Betis *
| 12.11.2008 | Real Betis | 2-0 | CD Castellón | |
| 29.10.2008 | CD Castellón | 0-2 | Real Betis | |
Real Unión 6-6 Real Madrid
| 11.11.2008 | Real Madrid | 4-3 | Real Unión | |
| 30.10.2008 | Real Unión | 3-2 | Real Madrid | |
Málaga CF 1-3 Real Mallorca *
| 12.11.2008 | Real Mallorca | 2-0 | Málaga CF | |
| 29.10.2008 | Málaga CF | 1-1 | Real Mallorca | |
*Athletic Bilbao 3-2 Recreativo Huelva
| 12.11.2008 | Recreativo Huelva | 2-1 | Athletic Bilbao | |
| 29.10.2008 | Athletic Bilbao | 2-0 | Recreativo Huelva | |
SD Ponferradina 1-4 Sevilla FC
| 13.11.2008 | Sevilla FC | 4-0 | SD Ponferradina | |
| 29.10.2008 | SD Ponferradina | 1-0 | Sevilla FC | |
*Polideportivo Ejido 6-1 Villarreal CF
| 12.11.2008 | Villarreal CF | 1-1 | Polideportivo Ejido | |
| 29.10.2008 | Polideportivo Ejido | 5-0 | Villarreal CF | |