*Atlético Madrid 2-1 RCD Espanyol
| 06.01.2011 | RCD Espanyol | 1-1 | Atlético Madrid | |
| 22.12.2010 | Atlético Madrid | 1-0 | RCD Espanyol | |
Córdoba CF 2-4 Deportivo La Coruña *
| 05.01.2011 | Deportivo La Coruña | 3-1 AET | Córdoba CF | |
| 21.12.2010 | Córdoba CF | 1-1 | Deportivo La Coruña | |
*FC Barcelona 1-1 Athletic Bilbao
| 05.01.2011 | Athletic Bilbao | 1-1 | FC Barcelona | |
| 21.12.2010 | FC Barcelona | 0-0 | Athletic Bilbao | |
*Sevilla FC 8-3 Málaga CF
| 05.01.2011 | Málaga CF | 0-3 | Sevilla FC | |
| 22.12.2010 | Sevilla FC | 5-3 | Málaga CF | |
*Real Betis 4-3 Getafe CF
| 06.01.2011 | Getafe CF | 1-3 | Real Betis | |
| 22.12.2010 | Real Betis | 1-2 | Getafe CF | |
*Real Madrid 8-2 Levante UD
| 06.01.2011 | Levante UD | 2-0 | Real Madrid | |
| 22.12.2010 | Real Madrid | 8-0 | Levante UD | |
*UD Almería 8-6 Real Mallorca
| 06.01.2011 | Real Mallorca | 3-4 | UD Almería | |
| 22.12.2010 | UD Almería | 4-3 | Real Mallorca | |
Valencia CF 2-4 Villarreal CF *
| 06.01.2011 | Villarreal CF | 4-2 | Valencia CF | |
| 21.12.2010 | Valencia CF | 0-0 | Villarreal CF | |