*Athletic Bilbao 8-0 SD Huesca
| 06.12.2018 | SD Huesca | 0-4 | Athletic Bilbao | |
| 28.11.2018 | Athletic Bilbao | 4-0 | SD Huesca | |
Cádiz CF 2-2 RCD Espanyol *
| 04.12.2018 | RCD Espanyol | 1-0 | Cádiz CF | |
| 01.11.2018 | Cádiz CF | 2-1 | RCD Espanyol | |
CD Ebro 1-3 Valencia CF *
| 04.12.2018 | Valencia CF | 1-0 | CD Ebro | |
| 30.10.2018 | CD Ebro | 1-2 | Valencia CF | |
*CD Leganés 3-2 Rayo Vallecano
| 04.12.2018 | Rayo Vallecano | 0-1 | CD Leganés | |
| 30.10.2018 | CD Leganés | 2-2 | Rayo Vallecano | |
Celta de Vigo 1-3 Real Sociedad *
| 05.12.2018 | Real Sociedad | 2-0 | Celta de Vigo | |
| 01.11.2018 | Celta de Vigo | 1-1 | Real Sociedad | |
Córdoba CF 2-7 Getafe CF *
| 04.12.2018 | Getafe CF | 5-1 | Córdoba CF | |
| 31.10.2018 | Córdoba CF | 1-2 | Getafe CF | |
Cultural Leonesa 1-5 FC Barcelona *
| 05.12.2018 | FC Barcelona | 4-1 | Cultural Leonesa | |
| 31.10.2018 | Cultural Leonesa | 0-1 | FC Barcelona | |
Deportivo Alavés 3-4 Girona FC *
| 05.12.2018 | Girona FC | 2-1 | Deportivo Alavés | |
| 31.10.2018 | Deportivo Alavés | 2-2 | Girona FC | |
CD Lugo 1-3 Levante UD *
| 06.12.2018 | Levante UD | 2-0 | CD Lugo | |
| 30.10.2018 | CD Lugo | 1-1 | Levante UD | |
Racing Santander 0-5 Real Betis *
| 06.12.2018 | Real Betis | 4-0 | Racing Santander | |
| 01.11.2018 | Racing Santander | 0-1 | Real Betis | |
Real Mallorca 2-4 Real Valladolid *
| 05.12.2018 | Real Valladolid | 2-1 | Real Mallorca | |
| 31.10.2018 | Real Mallorca | 1-2 | Real Valladolid | |
*Sporting Gijón 4-2 SD Eibar
| 06.12.2018 | SD Eibar | 2-2 | Sporting Gijón | |
| 01.11.2018 | Sporting Gijón | 2-0 | SD Eibar | |
CF Villanovense 0-1 Sevilla FC *
| 05.12.2018 | Sevilla FC | 1-0 | CF Villanovense | |
| 01.11.2018 | CF Villanovense | 0-0 | Sevilla FC | |
UD Melilla 1-10 Real Madrid *
| 06.12.2018 | Real Madrid | 6-1 | UD Melilla | |
| 31.10.2018 | UD Melilla | 0-4 | Real Madrid | |
UE Sant Andreu 0-5 Atlético Madrid *
| 05.12.2018 | Atlético Madrid | 4-0 | UE Sant Andreu | |
| 30.10.2018 | UE Sant Andreu | 0-1 | Atlético Madrid | |
UD Almería 3-11 Villarreal CF *
| 05.12.2018 | Villarreal CF | 8-0 | UD Almería | |
| 01.11.2018 | UD Almería | 3-3 | Villarreal CF | |