*Houston Dynamo 2-1 Sporting Kansas City
| 08.11.2012 | Sporting Kansas City | 1-0 | Houston Dynamo | |
| 04.11.2012 | Houston Dynamo | 2-0 | Sporting Kansas City | |
*Los Angeles Galaxy 3-2 San Jose Earthquake
| 08.11.2012 | San Jose Earthquake | 1-3 | Los Angeles Galaxy | |
| 05.11.2012 | Los Angeles Galaxy | 0-1 | San Jose Earthquake | |
*DC United 2-1 New York Red Bulls
| 09.11.2012 | New York Red Bulls | 0-1 | DC United | |
| 04.11.2012 | DC United | 1-1 | New York Red Bulls | |
*Seattle Sounders 1-0 Real Salt Lake
| 09.11.2012 | Real Salt Lake | 0-1 | Seattle Sounders | |
| 03.11.2012 | Seattle Sounders | 0-0 | Real Salt Lake | |