*Montreal Impact 5-2 Austin Aztex
| 10.10.2010 | Austin Aztex | 2-3 | Montreal Impact | |
| 07.10.2010 | Montreal Impact | 2-0 | Austin Aztex | |
NSC Minnesota Stars 0-4 Carolina Railhawks *
| 10.10.2010 | Carolina Railhawks | 4-0 | NSC Minnesota Stars | |
| 07.10.2010 | NSC Minnesota Stars | 0-0 | Carolina Railhawks | |
*Puerto Rico Islanders 3-2 Rochester Rhinos
| 10.10.2010 | Rochester Rhinos | 2-1 | Puerto Rico Islanders | |
| 08.10.2010 | Puerto Rico Islanders | 2-0 | Rochester Rhinos | |
*Vancouver WC 2-1 Portland Timbers
| 11.10.2010 | Portland Timbers | 1-0 | Vancouver WC | |
| 08.10.2010 | Vancouver WC | 2-0 | Portland Timbers | |