Airbus UK Broughton 4-3 Newtown AFC
| 08.09.2010 | Newtown AFC | 1-0 | Airbus UK Broughton | |
| 31.08.2010 | Airbus UK Broughton | 4-2 | Newtown AFC | |
Bala Town 2-4 Prestatyn Town
| 07.09.2010 | Prestatyn Town | 2-0 | Bala Town | |
| 31.08.2010 | Bala Town | 2-2 | Prestatyn Town | |
Carmarthen Town 0-3 Aberystwyth Town
| 07.09.2010 | Aberystwyth Town | 3-0 | Carmarthen Town | |
| 31.08.2010 | Carmarthen Town | 0-0 | Aberystwyth Town | |
Haverfordwest 4-3 Neath Athletic
| 08.09.2010 | Neath Athletic | 2-2 | Haverfordwest | |
| 31.08.2010 | Haverfordwest | 2-1 | Neath Athletic | |