*Kano Pillars 3-3 Ahly Cairo
| 02.05.2009 | Ahly Cairo | 2-2 | Kano Pillars | |
| 18.04.2009 | Kano Pillars | 1-1 | Ahly Cairo | |
1º de Agosto 3-3 Al Hilal Al Sudani
| 03.05.2009 | Al Hilal Al Sudani | 2-0 | 1º de Agosto | |
| 19.04.2009 | 1º de Agosto | 3-1 | Al Hilal Al Sudani | |
ASEC Mimosas 1-2 Monomotapa United *
| 03.05.2009 | Monomotapa United | 2-0 | ASEC Mimosas | |
| 19.04.2009 | ASEC Mimosas | 1-0 | Monomotapa United | |
*Heartland FC 3-2 Coton Sport
| 02.05.2009 | Coton Sport | 1-1 | Heartland FC | |
| 19.04.2009 | Heartland FC | 2-1 | Coton Sport | |
Djoliba AC 1-2 ZESCO United *
| 02.05.2009 | ZESCO United | 2-1 | Djoliba AC | |
| 19.04.2009 | Djoliba AC | 0-0 | ZESCO United | |
Al Ahli Tripoli 0-2 Étoile Sahel Sousse *
| 02.05.2009 | Étoile Sahel Sousse | 2-0 | Al Ahli Tripoli | |
| 18.04.2009 | Al Ahli Tripoli | 0-0 | Étoile Sahel Sousse | |
*TP Mazembe 1-0 Ittihad Khémisset
| 02.05.2009 | Ittihad Khémisset | 0-0 | TP Mazembe | |
| 19.04.2009 | TP Mazembe | 1-0 | Ittihad Khémisset | |
KCC Kampala 1-2 Merreikh Al Sudan *
| 02.05.2009 | Merreikh Al Sudan | 1-1 | KCC Kampala | |
| 17.04.2009 | KCC Kampala | 0-1 | Merreikh Al Sudan | |