*Wydad Casablanca 3-1 Aduana Stars
| 27.02.2011 | Aduana Stars | 1-0 | Wydad Casablanca | |
| 30.01.2011 | Wydad Casablanca | 3-0 | Aduana Stars | |
Zanzibar Ocean View 1-4 AS Vita Club *
| 27.02.2011 | AS Vita Club | 3-0 | Zanzibar Ocean View | |
| 30.01.2011 | Zanzibar Ocean View | 1-1 | AS Vita Club | |
*ASEC Mimosas 9-0 CF Cansado
| 26.02.2011 | CF Cansado | 0-2 | ASEC Mimosas | |
| 30.01.2011 | ASEC Mimosas | 7-0 | CF Cansado | |
Fello Star 1-4 ASFA Yennega *
| 12.02.2011 | ASFA Yennega | 3-0 | Fello Star | |
| 30.01.2011 | Fello Star | 1-1 | ASFA Yennega | |
*ASPAC Cotonou 2-1 Deportivo Mongomo
| 12.02.2011 | Deportivo Mongomo | 1-1 | ASPAC Cotonou | |
| 30.01.2011 | ASPAC Cotonou | 1-0 | Deportivo Mongomo | |
APR FC 2-6 Club Africain Tunis *
| 04.03.2011 | Club Africain Tunis | 4-0 | APR FC | |
| 29.01.2011 | APR FC | 2-2 | Club Africain Tunis | |
East End Lions FC 0-4 Djoliba AC *
| 05.03.2011 | Djoliba AC | 2-0 | East End Lions FC | |
| 30.01.2011 | East End Lions FC | 0-2 | Djoliba AC | |
*ASC Jaraaf 3-1 Gambia Ports A.
| 12.02.2011 | Gambia Ports A. | 0-2 | ASC Jaraaf | |
| 30.01.2011 | ASC Jaraaf | 1-1 | Gambia Ports A. | |
*Interclube Luanda 6-0 Township Rollers
| 11.02.2011 | Township Rollers | 0-3 W.O. | Interclube Luanda | |
| 30.01.2011 | Interclube Luanda | 3-0 W.O. | Township Rollers | |
ASFAN Niamey 0-3 JC Abidjan *
| 27.02.2011 | JC Abidjan | 3-0 | ASFAN Niamey | |
| 29.01.2011 | ASFAN Niamey | 0-0 | JC Abidjan | |
Mighty Barolle SA 1-3 Kano Pillars *
| 12.02.2011 | Kano Pillars | 1-0 | Mighty Barolle SA | |
| 30.01.2011 | Mighty Barolle SA | 1-2 | Kano Pillars | |
*US Bitam 0-0 Les Astres FC
| 05.03.2011 | Les Astres FC | 0-0/p.3-5 | US Bitam | |
| 30.01.2011 | US Bitam | 0-0 | Les Astres FC | |
*SuperSport United 3-2 Matlama FC
| 13.02.2011 | Matlama FC | 2-1 | SuperSport United | |
| 30.01.2011 | SuperSport United | 2-0 | Matlama FC | |
Olympic Real Bangui 1-3 MC Alger *
| 11.02.2011 | MC Alger | 2-0 | Olympic Real Bangui | |
| 30.01.2011 | Olympic Real Bangui | 1-1 | MC Alger | |
*Motor Action FC 1-1 CNaPS Sport
| 13.02.2011 | CNaPS Sport | 0-1/p.3-4 | Motor Action FC | |
| 30.01.2011 | Motor Action FC | 0-1 | CNaPS Sport | |
*Raja Casablanca 13-1 Tourbillon FC
| 11.02.2011 | Tourbillon FC | 0-3 W.O. | Raja Casablanca | |
| 28.01.2011 | Raja Casablanca | 10-1 | Tourbillon FC | |
*Recreativo Caála 2-1 Saint George SA
| 13.02.2011 | Saint George SA | 1-0 | Recreativo Caála | |
| 30.01.2011 | Recreativo Caála | 2-0 | Saint George SA | |
Saint Michel d'Ouenzé 0-3 Enyimba FC *
| 13.02.2011 | Enyimba FC | 2-0 | Saint Michel d'Ouenzé | |
| 30.01.2011 | Saint Michel d'Ouenzé | 0-1 | Enyimba FC | |
*Young Buffaloes 4-2 St Michel United
| 13.02.2011 | St Michel United | 2-1 | Young Buffaloes | |
| 30.01.2011 | Young Buffaloes | 3-0 | St Michel United | |
Vital'O FC 3-3 Coton Sport *
| 06.03.2011 | Coton Sport | 1-1 | Vital'O FC | |
| 30.01.2011 | Vital'O FC | 2-2 | Coton Sport | |
Ulinzi Stars 0-5 Zamalek SC *
| 27.02.2011 | Zamalek SC | 1-0 | Ulinzi Stars | |
| 29.01.2011 | Ulinzi Stars | 0-4 | Zamalek SC | |
*ZESCO United 4-2 Liga Muçulmana
| 12.02.2011 | Liga Muçulmana | 2-1 | ZESCO United | |
| 29.01.2011 | ZESCO United | 3-0 | Liga Muçulmana | |