*AC Léopard 2-1 Mounana FC
| 03.03.2013 | Mounana FC | 1-0 | AC Léopard | |
| 17.02.2013 | AC Léopard | 2-0 | Mounana FC | |
*AFAD Djékanou 6-2 Diamond Stars
| 02.03.2013 | Diamond Stars | 1-1 | AFAD Djékanou | |
| 17.02.2013 | AFAD Djékanou | 5-1 | Diamond Stars | |
*1º de Agosto 4-3 AS Adema
| 03.03.2013 | AS Adema | 1-0 | 1º de Agosto | |
| 16.02.2013 | 1º de Agosto | 4-2 | AS Adema | |
ASPAC Cotonou 2-2 ASFA Yennega *
| 03.03.2013 | ASFA Yennega | 1-1/p.5-4 | ASPAC Cotonou | |
| 17.02.2013 | ASPAC Cotonou | 1-1 | ASFA Yennega | |
Maghreb Tétouan 1-1 Casa Sport *
| 03.03.2013 | Casa Sport | 1-0/p.3-1 | Maghreb Tétouan | |
| 16.02.2013 | Maghreb Tétouan | 1-0 | Casa Sport | |
*Asante Kotoko 8-0 CD Elá Nguema
| 03.03.2013 | CD Elá Nguema | 0-1 | Asante Kotoko | |
| 17.02.2013 | Asante Kotoko | 7-0 | CD Elá Nguema | |
*Coton Sport 0-0 URA FC
| 02.03.2013 | URA FC | 0-0/p.3-4 | Coton Sport | |
| 17.02.2013 | Coton Sport | 0-0 | URA FC | |
*AS Vita Club 5-1 DYTO Lomé
| 03.03.2013 | DYTO Lomé | 1-2 | AS Vita Club | |
| 17.02.2013 | AS Vita Club | 3-0 | DYTO Lomé | |
*FUS Rabat 2-2 Real de Banjul
| 02.03.2013 | Real de Banjul | 2-1 | FUS Rabat | |
| 15.02.2013 | FUS Rabat | 1-0 | Real de Banjul | |
*CA Bizertin 2-1 Ittihad Tripoli
| 03.03.2013 | Ittihad Tripoli | 0-1 | CA Bizertin | |
| 15.02.2013 | CA Bizertin | 1-1 | Ittihad Tripoli | |
Jamhuri FC 0-8 Saint George SA *
| 03.03.2013 | Saint George SA | 5-0 | Jamhuri FC | |
| 16.02.2013 | Jamhuri FC | 0-3 | Saint George SA | |
*JSM Béjaia 3-0 Olympic de Niamey
| 01.03.2013 | Olympic de Niamey | 0-0 | JSM Béjaia | |
| 15.02.2013 | JSM Béjaia | 3-0 | Olympic de Niamey | |
*Dynamos FC 3-1 LCS FC
| 03.03.2013 | LCS FC | 1-0 | Dynamos FC | |
| 17.02.2013 | Dynamos FC | 3-0 | LCS FC | |
*Union Douala 3-1 LISCR Monrovia
| 03.03.2013 | LISCR Monrovia | 0-1 | Union Douala | |
| 17.02.2013 | Union Douala | 2-1 | LISCR Monrovia | |
CD Maxaquene 0-2 Mochudi Centre Chiefs *
| 02.03.2013 | Mochudi Centre Chiefs | 1-0 | CD Maxaquene | |
| 17.02.2013 | CD Maxaquene | 0-1 | Mochudi Centre Chiefs | |
*Kano Pillars 5-1 Olympic Real Bangui
| 03.03.2013 | Olympic Real Bangui | 0-0 | Kano Pillars | |
| 16.02.2013 | Kano Pillars | 5-1 | Olympic Real Bangui | |
Orlando Pirates 9-0 Djabal Club
| 02.03.2013 | Djabal Club | 0-4 | Orlando Pirates | |
| 16.02.2013 | Orlando Pirates | 5-0 | Djabal Club | |
Horoya AC 0-3 Séwé Sports *
| 02.03.2013 | Séwé Sports | 3-0 | Horoya AC | |
| 17.02.2013 | Horoya AC | 0-0 | Séwé Sports | |
Simba SC 0-5 Recreativo Libolo *
| 03.03.2013 | Recreativo Libolo | 4-0 | Simba SC | |
| 17.02.2013 | Simba SC | 0-1 | Recreativo Libolo | |
Enugu Rangers 6-0 Sporting Príncipe
| 02.03.2013 | Sporting Príncipe | 0-3 W.O. | Enugu Rangers | |
| 17.02.2013 | Enugu Rangers | 3-0 W.O. | Sporting Príncipe | |
St Michel United 1-7 Tusker FC *
| 02.03.2013 | Tusker FC | 3-0 | St Michel United | |
| 16.02.2013 | St Michel United | 1-4 | Tusker FC | |
APR FC 2-2 Vital'O FC *
| 03.03.2013 | Vital'O FC | 0-1 | APR FC | |
| 16.02.2013 | APR FC | 1-2 | Vital'O FC | |
*Zamalek SC 7-0 Gazelle N'Djamena
| 02.03.2013 | Gazelle N'Djamena | 0-0 | Zamalek SC | |
| 17.02.2013 | Zamalek SC | 7-0 | Gazelle N'Djamena | |
*Zanaco FC 3-2 Mbabane Swallows
| 03.03.2013 | Mbabane Swallows | 0-0 | Zanaco FC | |
| 16.02.2013 | Zanaco FC | 3-2 | Mbabane Swallows | |