Tusker FC 1-4 Al Ahly Cairo *
| 07.04.2013 | Al Ahly Cairo | 2-0 | Tusker FC | |
| 16.03.2013 | Tusker FC | 1-2 | Al Ahly Cairo | |
*Recreativo Libolo 4-2 Al Merreikh SC
| 06.04.2013 | Al Merreikh SC | 1-2 | Recreativo Libolo | |
| 17.03.2013 | Recreativo Libolo | 2-1 | Al Merreikh SC | |
ASFA Yennega 4-5 ES Sétif *
| 05.04.2013 | ES Sétif | 4-2 | ASFA Yennega | |
| 16.03.2013 | ASFA Yennega | 2-1 | ES Sétif | |
CA Bizertin 3-1 Dynamos FC
| 07.04.2013 | Dynamos FC | 1-0 | CA Bizertin | |
| 17.03.2013 | CA Bizertin | 3-0 | Dynamos FC | |
Casa Sport 1-4 Stade Malien *
| 06.04.2013 | Stade Malien | 2-0 | Casa Sport | |
| 17.03.2013 | Casa Sport | 1-2 | Stade Malien | |
AFAD Djékanou 1-3 Coton Sport *
| 07.04.2013 | Coton Sport | 2-1 | AFAD Djékanou | |
| 17.03.2013 | AFAD Djékanou | 0-1 | Coton Sport | |
1º de Agosto 0-2 Esperance ST *
| 06.04.2013 | Esperance ST | 1-0 | 1º de Agosto | |
| 17.03.2013 | 1º de Agosto | 0-1 | Esperance ST | |
*JSM Béjaia 1-1 Asante Kotoko
| 07.04.2013 | Asante Kotoko | 1-1 | JSM Béjaia | |
| 15.03.2013 | JSM Béjaia | 0-0 | Asante Kotoko | |
*Kano Pillars 4-1 AC Léopard
| 06.04.2013 | AC Léopard | 0-0 | Kano Pillars | |
| 16.03.2013 | Kano Pillars | 4-1 | AC Léopard | |
Mochudi Centre Chiefs 0-7 TP Mazembe *
| 07.04.2013 | TP Mazembe | 6-0 | Mochudi Centre Chiefs | |
| 16.03.2013 | Mochudi Centre Chiefs | 0-1 | TP Mazembe | |
Zanaco FC 1-3 Orlando Pirates *
| 06.04.2013 | Orlando Pirates | 2-1 | Zanaco FC | |
| 16.03.2013 | Zanaco FC | 0-1 | Orlando Pirates | |
*Saint George SA 3-1 Djoliba AC
| 07.04.2013 | Djoliba AC | 1-1 | Saint George SA | |
| 17.03.2013 | Saint George SA | 2-0 | Djoliba AC | |
*Séwé Sports 5-4 Al Hilal Al Sudani
| 05.04.2013 | Al Hilal Al Sudani | 3-1 | Séwé Sports | |
| 16.03.2013 | Séwé Sports | 4-1 | Al Hilal Al Sudani | |
*FUS Rabat 3-1 Union Douala
| 07.04.2013 | Union Douala | 1-0 | FUS Rabat | |
| 15.03.2013 | FUS Rabat | 3-0 | Union Douala | |
Vital'O FC 0-2 Enugu Rangers *
| 07.04.2013 | Enugu Rangers | 2-0 | Vital'O FC | |
| 17.03.2013 | Vital'O FC | 0-0 | Enugu Rangers | |
*Zamalek SC 1-0 AS Vita Club
| 06.04.2013 | AS Vita Club | 0-0 | Zamalek SC | |
| 15.03.2013 | Zamalek SC | 1-0 | AS Vita Club | |