*AC Léopard 4-4 ES Sétif
| 03.05.2013 | ES Sétif | 3-1/p.4-5 | AC Léopard | |
| 21.04.2013 | AC Léopard | 3-1 | ES Sétif | |
CA Bizertin 1-2 Ahly Cairo *
| 05.05.2013 | Ahly Cairo | 2-1 | CA Bizertin | |
| 21.04.2013 | CA Bizertin | 0-0 | Ahly Cairo | |
FUS Rabat 1-1 Séwé Sports *
| 04.05.2013 | Séwé Sports | 0-0 | FUS Rabat | |
| 21.04.2013 | FUS Rabat | 1-1 | Séwé Sports | |
JSM Béjaia 0-1 Esperance ST *
| 04.05.2013 | Esperance ST | 1-0 | JSM Béjaia | |
| 20.04.2013 | JSM Béjaia | 0-0 | Esperance ST | |
*Orlando Pirates 3-2 TP Mazembe
| 05.05.2013 | TP Mazembe | 1-0 | Orlando Pirates | |
| 20.04.2013 | Orlando Pirates | 3-1 | TP Mazembe | |
Enugu Rangers 1-3 Recreativo Libolo *
| 04.05.2013 | Recreativo Libolo | 3-1 | Enugu Rangers | |
| 21.04.2013 | Enugu Rangers | 0-0 | Recreativo Libolo | |
*Coton Sport 3-0 Stade Malien
| 04.05.2013 | Stade Malien | 0-0 | Coton Sport | |
| 21.04.2013 | Coton Sport | 3-0 | Stade Malien | |
*Zamalek SC 3-3 Saint George SA
| 05.05.2013 | Saint George SA | 2-2 | Zamalek SC | |
| 20.04.2013 | Zamalek SC | 1-1 | Saint George SA | |