Gor Mahia 0-2 AC Léopard *
| 05.04.2015 | AC Léopard | 1-0 | Gor Mahia | |
| 15.03.2015 | Gor Mahia | 0-1 | AC Léopard | |
AC Semassi 0-6 CS Sfaxien *
| 05.04.2015 | CS Sfaxien | 1-0 | AC Semassi | |
| 15.03.2015 | AC Semassi | 0-5 | CS Sfaxien | |
APR FC 0-4 Al Ahly Cairo *
| 04.04.2015 | Al Ahly Cairo | 2-0 | APR FC | |
| 14.03.2015 | APR FC | 0-2 | Al Ahly Cairo | |
*Al Merreikh SC 3-2 Kabuscorp SC
| 04.04.2015 | Kabuscorp SC | 2-1 | Al Merreikh SC | |
| 14.03.2015 | Al Merreikh SC | 2-0 | Kabuscorp SC | |
ZESCO United 2-2 AS Kaloum Star *
| 05.04.2015 | AS Kaloum Star | 1-1/p.5-4 | ZESCO United | |
| 14.03.2015 | ZESCO United | 1-1 | AS Kaloum Star | |
AS Mangasport 2-5 Stade Malien *
| 04.04.2015 | Stade Malien | 2-1 | AS Mangasport | |
| 14.03.2015 | AS Mangasport | 1-3 | Stade Malien | |
*MC El Eulma 2-1 Asante Kotoko
| 05.04.2015 | Asante Kotoko | 1-2 | MC El Eulma | |
| 14.03.2015 | MC El Eulma | 0-0 | Asante Kotoko | |
Cosmos de Bafia 1-4 Esperance ST *
| 05.04.2015 | Esperance ST | 3-1 | Cosmos de Bafia | |
| 15.03.2015 | Cosmos de Bafia | 0-1 | Esperance ST | |
Coton Sport 0-2 SM Sanga Balende *
| 05.04.2015 | SM Sanga Balende | 2-0 | Coton Sport | |
| 14.03.2015 | Coton Sport | 0-0 | SM Sanga Balende | |
Real de Banjul 1-3 ES Sétif *
| 03.04.2015 | ES Sétif | 2-0 | Real de Banjul | |
| 14.03.2015 | Real de Banjul | 1-1 | ES Sétif | |
*Maghreb Tétouan 5-2 Kano Pillars
| 04.04.2015 | Kano Pillars | 2-1 | Maghreb Tétouan | |
| 21.03.2015 | Maghreb Tétouan | 4-0 | Kano Pillars | |
*Al Hilal Al Sudani 5-1 Nyasa Big Bullets
| 05.04.2015 | Nyasa Big Bullets | 1-1 | Al Hilal Al Sudani | |
| 15.03.2015 | Al Hilal Al Sudani | 4-0 | Nyasa Big Bullets | |
Kaizer Chiefs 0-3 Raja Casablanca *
| 05.04.2015 | Raja Casablanca | 2-0 | Kaizer Chiefs | |
| 14.03.2015 | Kaizer Chiefs | 0-1 | Raja Casablanca | |
Enyimba FC 1-2 Semouha Club *
| 05.04.2015 | Semouha Club | 2-0 | Enyimba FC | |
| 15.03.2015 | Enyimba FC | 1-0 | Semouha Club | |
Mamelodi Sundowns 2-3 TP Mazembe *
| 05.04.2015 | TP Mazembe | 3-1 | Mamelodi Sundowns | |
| 14.03.2015 | Mamelodi Sundowns | 1-0 | TP Mazembe | |