Onze Créateurs 1-2 Al Ahli Tripoli *
| 26.02.2016 | Al Ahli Tripoli | 0-0 | Onze Créateurs | |
| 14.02.2016 | Onze Créateurs | 1-2 | Al Ahli Tripoli | |
Mbabane Swallows 2-4 APR FC *
| 27.02.2016 | APR FC | 4-1 | Mbabane Swallows | |
| 14.02.2016 | Mbabane Swallows | 1-0 | APR FC | |
AS Mangasport 0-3 Étoile du Congo *
| 28.02.2016 | Étoile du Congo | 3-0 | AS Mangasport | |
| 13.02.2016 | AS Mangasport | 0-0 | Étoile du Congo | |
*Club Africain Tunis 2-0 AS Tanda
| 26.02.2016 | AS Tanda | 0-0 | Club Africain Tunis | |
| 14.02.2016 | Club Africain Tunis | 2-0 | AS Tanda | |
AS CotonTchad 0-1 ASEC Mimosas *
| 28.02.2016 | ASEC Mimosas | 0-0 | AS CotonTchad | |
| 14.02.2016 | AS CotonTchad | 0-1 | ASEC Mimosas | |
Chicken Inn 1-2 Mamelodi Sundowns *
| 27.02.2016 | Mamelodi Sundowns | 2-0 | Chicken Inn | |
| 13.02.2016 | Chicken Inn | 1-0 | Mamelodi Sundowns | |
Gor Mahia 1-3 CNaPS Sport *
| 27.02.2016 | CNaPS Sport | 1-0 | Gor Mahia | |
| 13.02.2016 | Gor Mahia | 1-2 | CNaPS Sport | |
AS Douanes Dakar 0-4 Horoya AC *
| 28.02.2016 | Horoya AC | 4-0 | AS Douanes Dakar | |
| 13.02.2016 | AS Douanes Dakar | 0-0 | Horoya AC | |
Mafunzo FC 0-4 AS Vita Club *
| 28.02.2016 | AS Vita Club | 1-0 | Mafunzo FC | |
| 13.02.2016 | Mafunzo FC | 0-3 | AS Vita Club | |
Ashanti Gold SC 2-3 MO Béjaïa *
| 28.02.2016 | MO Béjaïa | 3-1 | Ashanti Gold SC | |
| 14.02.2016 | Ashanti Gold SC | 1-0 | MO Béjaïa | |
Mochudi Centre Chiefs 0-6 Ferroviário Maputo *
| 26.02.2016 | Ferroviário Maputo | 3-0 W.O. | Mochudi Centre Chiefs | |
| 12.02.2016 | Mochudi Centre Chiefs | 0-3 W.O. | Ferroviário Maputo | |
*OC Khouribga 4-2 GAMTEL FC
| 27.02.2016 | GAMTEL FC | 1-2 | OC Khouribga | |
| 12.02.2016 | OC Khouribga | 2-1 | GAMTEL FC | |
*Recreativo Libolo 9-1 Racing de Micomeseng
| 28.02.2016 | Racing de Micomeseng | 0-4 | Recreativo Libolo | |
| 13.02.2016 | Recreativo Libolo | 5-1 | Racing de Micomeseng | |
*Warri Wolves 6-0 Sporting Praia Cruz
| 26.02.2016 | Sporting Praia Cruz | 0-3 W.O. | Warri Wolves | |
| 14.02.2016 | Warri Wolves | 3-0 W.O. | Sporting Praia Cruz | |
*Saint George SA 4-1 St Michel United
| 27.02.2016 | St Michel United | 1-1 | Saint George SA | |
| 14.02.2016 | Saint George SA | 3-0 | St Michel United | |
*Stade Malien 4-1 Racing Club Bobo
| 28.02.2016 | Racing Club Bobo | 0-1 | Stade Malien | |
| 13.02.2016 | Stade Malien | 3-1 | Racing Club Bobo | |
Nimba United 1-4 Union Douala *
| 28.02.2016 | Union Douala | 1-0 | Nimba United | |
| 14.02.2016 | Nimba United | 1-3 | Union Douala | |
Vipers SC 1-2 Enyimba FC *
| 28.02.2016 | Enyimba FC | 2-0 | Vipers SC | |
| 12.02.2016 | Vipers SC | 1-0 | Enyimba FC | |
Lioli FC 2-2 Vital'O FC *
| 28.02.2016 | Vital'O FC | 0-1 | Lioli FC | |
| 14.02.2016 | Lioli FC | 1-2 | Vital'O FC | |
Volcan Club 0-7 Kaizer Chiefs *
| 28.02.2016 | Kaizer Chiefs | 3-0 W.O. | Volcan Club | |
| 14.02.2016 | Volcan Club | 0-4 | Kaizer Chiefs | |
*Wydad Casablanca 3-2 AS Douanes Niamey
| 06.03.2016 | AS Douanes Niamey | 2-1 | Wydad Casablanca | |
| 14.02.2016 | Wydad Casablanca | 2-0 | AS Douanes Niamey | |
Cercle de Joachim 0-3 Young Africans *
| 27.02.2016 | Young Africans | 2-0 | Cercle de Joachim | |
| 13.02.2016 | Cercle de Joachim | 0-1 | Young Africans | |
*ZESCO United 3-0 Al Ghazal FC
| 26.02.2016 | Al Ghazal FC | 0-1 | ZESCO United | |
| 14.02.2016 | ZESCO United | 2-0 | Al Ghazal FC | |