*Mamelodi Sundowns 3-1 AC Léopard
| 19.03.2016 | AC Léopard | 1-1 | Mamelodi Sundowns | |
| 12.03.2016 | Mamelodi Sundowns | 2-0 | AC Léopard | |
*Al Ahli Tripoli 2-2 Al Hilal Al Sudani
| 20.03.2016 | Al Hilal Al Sudani | 2-1 | Al Ahli Tripoli | |
| 12.03.2016 | Al Ahli Tripoli | 1-0 | Al Hilal Al Sudani | |
Recreativo Libolo 0-2 Al Ahly Cairo *
| 19.03.2016 | Al Ahly Cairo | 2-0 | Recreativo Libolo | |
| 12.03.2016 | Recreativo Libolo | 0-0 | Al Ahly Cairo | |
Warri Wolves 0-2 Al Merreikh SC *
| 19.03.2016 | Al Merreikh SC | 1-0 | Warri Wolves | |
| 13.03.2016 | Warri Wolves | 0-1 | Al Merreikh SC | |
APR FC 2-3 Young Africans *
| 19.03.2016 | Young Africans | 1-1 | APR FC | |
| 12.03.2016 | APR FC | 1-2 | Young Africans | |
*AS Vita Club 2-1 Ferroviário Maputo
| 20.03.2016 | Ferroviário Maputo | 1-1 | AS Vita Club | |
| 13.03.2016 | AS Vita Club | 1-0 | Ferroviário Maputo | |
Club Africain Tunis 1-2 MO Béjaïa *
| 20.03.2016 | MO Béjaïa | 2-0 | Club Africain Tunis | |
| 12.03.2016 | Club Africain Tunis | 1-0 | MO Béjaïa | |
*Wydad Casablanca 6-3 CNaPS Sport
| 19.03.2016 | CNaPS Sport | 2-1 | Wydad Casablanca | |
| 12.03.2016 | Wydad Casablanca | 5-1 | CNaPS Sport | |
*Stade Malien 2-1 Coton Sport
| 20.03.2016 | Coton Sport | 1-0 | Stade Malien | |
| 12.03.2016 | Stade Malien | 2-0 | Coton Sport | |
*Enyimba FC 6-3 Vital'O FC
| 19.03.2016 | Vital'O FC | 2-1 | Enyimba FC | |
| 13.03.2016 | Enyimba FC | 5-1 | Vital'O FC | |
Étoile du Congo 3-5 ES Sétif *
| 20.03.2016 | ES Sétif | 4-2 | Étoile du Congo | |
| 13.03.2016 | Étoile du Congo | 1-1 | ES Sétif | |
OC Khouribga 1-3 Étoile Sahel Sousse *
| 19.03.2016 | Étoile Sahel Sousse | 2-0 | OC Khouribga | |
| 13.03.2016 | OC Khouribga | 1-1 | Étoile Sahel Sousse | |
*ZESCO United 4-3 Horoya AC
| 20.03.2016 | Horoya AC | 2-0 | ZESCO United | |
| 12.03.2016 | ZESCO United | 4-1 | Horoya AC | |
Kaizer Chiefs 0-1 ASEC Mimosas *
| 20.03.2016 | ASEC Mimosas | 0-0 | Kaizer Chiefs | |
| 12.03.2016 | Kaizer Chiefs | 0-1 | ASEC Mimosas | |
Saint George SA 2-3 TP Mazembe *
| 20.03.2016 | TP Mazembe | 1-0 | Saint George SA | |
| 13.03.2016 | Saint George SA | 2-2 | TP Mazembe | |
Union Douala 0-3 Zamalek SC *
| 19.03.2016 | Zamalek SC | 2-0 | Union Douala | |
| 13.03.2016 | Union Douala | 0-1 | Zamalek SC | |