AC Léopard 0-3 Saint George SA *
| 19.03.2017 | Saint George SA | 2-0 | AC Léopard | |
| 12.03.2017 | AC Léopard | 0-1 | Saint George SA | |
*Al Ahli Tripoli 3-3 FUS Rabat
| 18.03.2017 | FUS Rabat | 3-1 | Al Ahli Tripoli | |
| 12.03.2017 | Al Ahli Tripoli | 2-0 | FUS Rabat | |
*Al Ahly Cairo 1-0 Bidvest Wits
| 19.03.2017 | Bidvest Wits | 0-0 | Al Ahly Cairo | |
| 11.03.2017 | Al Ahly Cairo | 1-0 | Bidvest Wits | |
*Al Hilal Al Sudani 5-2 AS Port-Louis 2000
| 19.03.2017 | AS Port-Louis 2000 | 2-2 | Al Hilal Al Sudani | |
| 12.03.2017 | Al Hilal Al Sudani | 3-0 | AS Port-Louis 2000 | |
*Étoile Sahel Sousse 5-1 AS Tanda
| 19.03.2017 | AS Tanda | 1-2 | Étoile Sahel Sousse | |
| 12.03.2017 | Étoile Sahel Sousse | 3-0 | AS Tanda | |
Gambia Ports A. 1-3 AS Vita Club *
| 19.03.2017 | AS Vita Club | 2-0 | Gambia Ports A. | |
| 12.03.2017 | Gambia Ports A. | 1-1 | AS Vita Club | |
*Ferroviário da Beira 2-2 BYC FC
| 19.03.2017 | BYC FC | 2-0/p.1-4 | Ferroviário da Beira | |
| 12.03.2017 | Ferroviário da Beira | 2-0 | BYC FC | |
*Coton Sport 2-1 CNaPS Sport
| 18.03.2017 | CNaPS Sport | 1-1 | Coton Sport | |
| 12.03.2017 | Coton Sport | 1-0 | CNaPS Sport | |
*Zamalek SC 5-3 Enugu Rangers
| 19.03.2017 | Enugu Rangers | 2-1 | Zamalek SC | |
| 12.03.2017 | Zamalek SC | 4-1 | Enugu Rangers | |
*Esperance ST 4-3 Horoya AC
| 19.03.2017 | Horoya AC | 2-1 | Esperance ST | |
| 11.03.2017 | Esperance ST | 3-1 | Horoya AC | |
*Mamelodi Sundowns 3-2 KCCA FC
| 18.03.2017 | KCCA FC | 1-1 | Mamelodi Sundowns | |
| 10.03.2017 | Mamelodi Sundowns | 2-1 | KCCA FC | |
Rivers United 3-4 Al Merreikh SC *
| 18.03.2017 | Al Merreikh SC | 4-0 | Rivers United | |
| 12.03.2017 | Rivers United | 3-0 | Al Merreikh SC | |
TP Mazembe 1-1 CAPS United FC *
| 19.03.2017 | CAPS United FC | 0-0 | TP Mazembe | |
| 12.03.2017 | TP Mazembe | 1-1 | CAPS United FC | |
*USM Alger 2-1 Rail Club Kadiogo
| 18.03.2017 | Rail Club Kadiogo | 1-0 | USM Alger | |
| 11.03.2017 | USM Alger | 2-0 | Rail Club Kadiogo | |
*Wydad Casablanca 1-1 CF Mounana
| 18.03.2017 | CF Mounana | 1-0/p.4-5 | Wydad Casablanca | |
| 11.03.2017 | Wydad Casablanca | 1-0 | CF Mounana | |
Young Africans 1-1 Zanaco FC *
| 18.03.2017 | Zanaco FC | 0-0 | Young Africans | |
| 11.03.2017 | Young Africans | 1-1 | Zanaco FC | |