AC Léopard 3-3 AS Togo-Port *
| 21.02.2018 | AS Togo-Port | 2-1/p.4-3 | AC Léopard | |
| 10.02.2018 | AC Léopard | 2-1 | AS Togo-Port | |
Tahaddy Benghazi 1-2 Aduana Stars *
| 21.02.2018 | Aduana Stars | 2-0 | Tahaddy Benghazi | |
| 11.02.2018 | Tahaddy Benghazi | 1-0 | Aduana Stars | |
LISCR Monrovia 1-3 Al Hilal Al Sudani *
| 20.02.2018 | Al Hilal Al Sudani | 3-0 | LISCR Monrovia | |
| 11.02.2018 | LISCR Monrovia | 1-0 | Al Hilal Al Sudani | |
*AS Génération Foot 2-0 Masr lel Maqassah
| 21.02.2018 | Masr lel Maqassah | 0-0 | AS Génération Foot | |
| 10.02.2018 | AS Génération Foot | 2-0 | Masr lel Maqassah | |
AS Real Bamako 1-2 MFM FC *
| 21.02.2018 | MFM FC | 1-0 | AS Real Bamako | |
| 11.02.2018 | AS Real Bamako | 1-1 | MFM FC | |
*AS Vita Club 6-1 Mighty Mukuru Wanderers
| 21.02.2018 | Mighty Mukuru Wanderers | 1-2 | AS Vita Club | |
| 11.02.2018 | AS Vita Club | 4-0 | Mighty Mukuru Wanderers | |
Bantu FC 5-5 Mbabane Swallows *
| 21.02.2018 | Mbabane Swallows | 1-3 | Bantu FC | |
| 11.02.2018 | Bantu FC | 2-4 | Mbabane Swallows | |
*Difaâ El Jadidi 10-0 Benfica de Bissau
| 21.02.2018 | Benfica de Bissau | 0-0 | Difaâ El Jadidi | |
| 10.02.2018 | Difaâ El Jadidi | 10-0 | Benfica de Bissau | |
Buffles du Borgou 3-4 ASEC Mimosas *
| 21.02.2018 | ASEC Mimosas | 3-2 | Buffles du Borgou | |
| 11.02.2018 | Buffles du Borgou | 1-1 | ASEC Mimosas | |
Rail Club Kadiogo 1-2 CF Mounana *
| 21.02.2018 | CF Mounana | 2-0 | Rail Club Kadiogo | |
| 10.02.2018 | Rail Club Kadiogo | 1-0 | CF Mounana | |
CNaPS Sport 2-2 KCCA FC *
| 21.02.2018 | KCCA FC | 1-0 | CNaPS Sport | |
| 10.02.2018 | CNaPS Sport | 2-1 | KCCA FC | |
*Plateau United 4-0 Eding Sport
| 21.02.2018 | Eding Sport | 0-1 | Plateau United | |
| 11.02.2018 | Plateau United | 3-0 | Eding Sport | |
ASAC Concorde 1-6 Esperance ST *
| 21.02.2018 | Esperance ST | 5-0 | ASAC Concorde | |
| 10.02.2018 | ASAC Concorde | 1-1 | Esperance ST | |
*1º de Agosto 5-1 FC Platinum (ZIM)
| 21.02.2018 | FC Platinum (ZIM) | 1-2 | 1º de Agosto | |
| 11.02.2018 | 1º de Agosto | 3-0 | FC Platinum (ZIM) | |
ASFAN Niamey 1-3 Horoya AC *
| 21.02.2018 | Horoya AC | 0-0 | ASFAN Niamey | |
| 10.02.2018 | ASFAN Niamey | 1-3 | Horoya AC | |
JKU FC 0-7 ZESCO United *
| 21.02.2018 | ZESCO United | 7-0 | JKU FC | |
| 10.02.2018 | JKU FC | 0-0 | ZESCO United | |
*Gor Mahia 3-1 Leones Vegetarianos
| 21.02.2018 | Leones Vegetarianos | 1-1 | Gor Mahia | |
| 10.02.2018 | Gor Mahia | 2-0 | Leones Vegetarianos | |
Ngaya Club 1-3 UD Songo *
| 21.02.2018 | UD Songo | 2-0 | Ngaya Club | |
| 11.02.2018 | Ngaya Club | 1-1 | UD Songo | |
*ES Sétif 6-0 Olympic Real Bangui
| 20.02.2018 | Olympic Real Bangui | 0-0 | ES Sétif | |
| 11.02.2018 | ES Sétif | 6-0 | Olympic Real Bangui | |
*Bidvest Wits 2-1 Pamplemousses
| 21.02.2018 | Pamplemousses | 1-0 | Bidvest Wits | |
| 10.02.2018 | Bidvest Wits | 2-0 | Pamplemousses | |
*Rayon Sports 2-1 LLB S4 Africa
| 21.02.2018 | LLB S4 Africa | 0-1 | Rayon Sports | |
| 10.02.2018 | Rayon Sports | 1-1 | LLB S4 Africa | |
*Saint George SA 6-0 Wau Salaam
| 20.02.2018 | Wau Salaam | 0-3 W.O. | Saint George SA | |
| 11.02.2018 | Saint George SA | 3-0 W.O. | Wau Salaam | |
*Young Africans 2-1 St Louis Suns United
| 21.02.2018 | St Louis Suns United | 1-1 | Young Africans | |
| 10.02.2018 | Young Africans | 1-0 | St Louis Suns United | |
*Township Rollers 4-2 Merreikh Al Sudan
| 21.02.2018 | Merreikh Al Sudan | 2-1 | Township Rollers | |
| 10.02.2018 | Township Rollers | 3-0 | Merreikh Al Sudan | |
Stade Malien 1-2 Williamsville AC *
| 20.02.2018 | Williamsville AC | 1-0 | Stade Malien | |
| 10.02.2018 | Stade Malien | 1-1 | Williamsville AC | |
*Zanaco FC 6-1 Armed Forces FC
| 24.02.2018 | Armed Forces FC | 1-3 | Zanaco FC | |
| 10.02.2018 | Zanaco FC | 3-0 | Armed Forces FC | |