*1º de Agosto 1-1 Bidvest Wits
| 17.03.2018 | Bidvest Wits | 1-0/p.2-3 | 1º de Agosto | |
| 07.03.2018 | 1º de Agosto | 1-0 | Bidvest Wits | |
Aduana Stars 1-4 ES Sétif *
| 18.03.2018 | ES Sétif | 4-0 | Aduana Stars | |
| 07.03.2018 | Aduana Stars | 1-0 | ES Sétif | |
*AS Togo-Port 3-3 Al Hilal Al Sudani
| 18.03.2018 | Al Hilal Al Sudani | 3-1 | AS Togo-Port | |
| 07.03.2018 | AS Togo-Port | 2-0 | Al Hilal Al Sudani | |
*Al Ahly Cairo 7-1 CF Mounana
| 17.03.2018 | CF Mounana | 1-3 | Al Ahly Cairo | |
| 06.03.2018 | Al Ahly Cairo | 4-0 | CF Mounana | |
*Difaâ El Jadidi 3-2 AS Vita Club
| 18.03.2018 | AS Vita Club | 2-2 | Difaâ El Jadidi | |
| 07.03.2018 | Difaâ El Jadidi | 1-0 | AS Vita Club | |
Gor Mahia 0-1 Esperance ST *
| 18.03.2018 | Esperance ST | 1-0 | Gor Mahia | |
| 07.03.2018 | Gor Mahia | 0-0 | Esperance ST | |
*Horoya AC 4-1 AS Génération Foot
| 17.03.2018 | AS Génération Foot | 0-2 | Horoya AC | |
| 06.03.2018 | Horoya AC | 2-1 | AS Génération Foot | |
Saint George SA 0-1 KCCA FC *
| 17.03.2018 | KCCA FC | 1-0 | Saint George SA | |
| 07.03.2018 | Saint George SA | 0-0 | KCCA FC | |
Rayon Sports 0-2 Mamelodi Sundowns *
| 18.03.2018 | Mamelodi Sundowns | 2-0 | Rayon Sports | |
| 07.03.2018 | Rayon Sports | 0-0 | Mamelodi Sundowns | |
Zanaco FC 1-3 Mbabane Swallows *
| 17.03.2018 | Mbabane Swallows | 1-0 | Zanaco FC | |
| 07.03.2018 | Zanaco FC | 1-2 | Mbabane Swallows | |
*Étoile Sahel Sousse 4-3 Plateau United
| 18.03.2018 | Plateau United | 1-0 | Étoile Sahel Sousse | |
| 06.03.2018 | Étoile Sahel Sousse | 4-2 | Plateau United | |
Young Africans 1-2 Township Rollers *
| 17.03.2018 | Township Rollers | 0-0 | Young Africans | |
| 06.03.2018 | Young Africans | 1-2 | Township Rollers | |
*TP Mazembe 4-3 UD Songo
| 17.03.2018 | UD Songo | 3-0 | TP Mazembe | |
| 07.03.2018 | TP Mazembe | 4-0 | UD Songo | |
*Wydad Casablanca 7-4 Williamsville AC
| 17.03.2018 | Williamsville AC | 2-0 | Wydad Casablanca | |
| 07.03.2018 | Wydad Casablanca | 7-2 | Williamsville AC | |
*ZESCO United 2-2 ASEC Mimosas
| 18.03.2018 | ASEC Mimosas | 1-2 | ZESCO United | |
| 07.03.2018 | ZESCO United | 0-1 | ASEC Mimosas | |