*Orlando Pirates 1-0 African Stars FC
| 22.12.2018 | African Stars FC | 0-1 | Orlando Pirates | |
| 15.12.2018 | Orlando Pirates | 0-0 | African Stars FC | |
AS Otôho 1-1 FC Platinum (ZIM) *
| 22.12.2018 | FC Platinum (ZIM) | 0-0 | AS Otôho | |
| 16.12.2018 | AS Otôho | 1-1 | FC Platinum (ZIM) | |
*AS Vita Club 5-2 Bantu FC
| 23.12.2018 | Bantu FC | 1-1 | AS Vita Club | |
| 16.12.2018 | AS Vita Club | 4-1 | Bantu FC | |
Stade Malien 0-2 ASEC Mimosas *
| 23.12.2018 | ASEC Mimosas | 1-0 | Stade Malien | |
| 15.12.2018 | Stade Malien | 0-1 | ASEC Mimosas | |
*Club Africain Tunis 3-2 Al Hilal Al Sudani
| 23.12.2018 | Al Hilal Al Sudani | 1-0 | Club Africain Tunis | |
| 16.12.2018 | Club Africain Tunis | 3-1 | Al Hilal Al Sudani | |
*CS Constantine 3-0 Vipers SC
| 22.12.2018 | Vipers SC | 0-2 | CS Constantine | |
| 14.12.2018 | CS Constantine | 1-0 | Vipers SC | |
Gor Mahia 3-3 Lobi Stars *
| 22.12.2018 | Lobi Stars | 2-0 | Gor Mahia | |
| 16.12.2018 | Gor Mahia | 3-1 | Lobi Stars | |
Nasr Benghazi 5-6 Horoya AC *
| 23.12.2018 | Horoya AC | 6-2 | Nasr Benghazi | |
| 14.12.2018 | Nasr Benghazi | 3-0 | Horoya AC | |
*Ismaily SC 3-2 Coton Sport
| 22.12.2018 | Coton Sport | 2-1 | Ismaily SC | |
| 16.12.2018 | Ismaily SC | 2-0 | Coton Sport | |
*Ahly Cairo 2-1 Jimma Aba Jifar
| 23.12.2018 | Jimma Aba Jifar | 1-0 | Ahly Cairo | |
| 14.12.2018 | Ahly Cairo | 2-0 | Jimma Aba Jifar | |
*JS Saoura 2-1 Ittihad Tanger
| 23.12.2018 | Ittihad Tanger | 1-0 | JS Saoura | |
| 15.12.2018 | JS Saoura | 2-0 | Ittihad Tanger | |
Al Ahli Benghazi 0-4 Mamelodi Sundowns *
| 22.12.2018 | Mamelodi Sundowns | 4-0 | Al Ahli Benghazi | |
| 16.12.2018 | Al Ahli Benghazi | 0-0 | Mamelodi Sundowns | |
*Wydad Casablanca 3-3 ASC Jaraaf
| 22.12.2018 | ASC Jaraaf | 3-1 | Wydad Casablanca | |
| 15.12.2018 | Wydad Casablanca | 2-0 | ASC Jaraaf | |
*TP Mazembe 2-1 ZESCO United
| 22.12.2018 | ZESCO United | 1-1 | TP Mazembe | |
| 16.12.2018 | TP Mazembe | 1-0 | ZESCO United | |