Green Eagles 2-2 1º de Agosto *
| 29.09.2019 | 1º de Agosto | 0-1 | Green Eagles | |
| 14.09.2019 | Green Eagles | 1-2 | 1º de Agosto | |
Cano Sport 0-6 Al Ahly Cairo *
| 28.09.2019 | Al Ahly Cairo | 4-0 | Cano Sport | |
| 14.09.2019 | Cano Sport | 0-2 | Al Ahly Cairo | |
Enyimba FC 0-1 Al Hilal Al Sudani *
| 29.09.2019 | Al Hilal Al Sudani | 1-0 | Enyimba FC | |
| 15.09.2019 | Enyimba FC | 0-0 | Al Hilal Al Sudani | |
ASC Kara 0-1 AS Vita Club *
| 29.09.2019 | AS Vita Club | 1-0 | ASC Kara | |
| 15.09.2019 | ASC Kara | 0-0 | AS Vita Club | |
Côte d'Or FC 1-16 Mamelodi Sundowns *
| 27.09.2019 | Mamelodi Sundowns | 11-1 | Côte d'Or FC | |
| 14.09.2019 | Côte d'Or FC | 0-5 | Mamelodi Sundowns | |
Elect Sport FC 2-3 Esperance ST *
| 27.09.2019 | Esperance ST | 2-1 | Elect Sport FC | |
| 15.09.2019 | Elect Sport FC | 1-1 | Esperance ST | |
Asante Kotoko 2-3 Étoile Sahel Sousse *
| 29.09.2019 | Étoile Sahel Sousse | 3-0 | Asante Kotoko | |
| 15.09.2019 | Asante Kotoko | 2-0 | Étoile Sahel Sousse | |
FC Nouadhibou 1-6 Wydad Casablanca *
| 29.09.2019 | Wydad Casablanca | 4-1 | FC Nouadhibou | |
| 15.09.2019 | FC Nouadhibou | 0-2 | Wydad Casablanca | |
*FC Platinum (ZIM) 5-2 UD Songo
| 28.09.2019 | UD Songo | 2-4 | FC Platinum (ZIM) | |
| 14.09.2019 | FC Platinum (ZIM) | 1-0 | UD Songo | |
*JS Kabylie 2-2 Horoya AC
| 29.09.2019 | Horoya AC | 2-0/p.3-5 | JS Kabylie | |
| 14.09.2019 | JS Kabylie | 2-0 | Horoya AC | |
*Petro Atlético Luanda 1-1 KCCA FC
| 27.09.2019 | KCCA FC | 1-1 | Petro Atlético Luanda | |
| 14.09.2019 | Petro Atlético Luanda | 0-0 | KCCA FC | |
Nasr Benghazi 2-4 Raja Casablanca *
| 28.09.2019 | Raja Casablanca | 1-1 | Nasr Benghazi | |
| 15.09.2019 | Nasr Benghazi | 1-3 | Raja Casablanca | |
Fosa Juniors 1-3 TP Mazembe *
| 29.09.2019 | TP Mazembe | 3-1 | Fosa Juniors | |
| 15.09.2019 | Fosa Juniors | 0-0 | TP Mazembe | |
Young Africans 2-3 ZESCO United *
| 28.09.2019 | ZESCO United | 2-1 | Young Africans | |
| 14.09.2019 | Young Africans | 1-1 | ZESCO United | |
AS Génération Foot 2-2 Zamalek SC *
| 24.10.2019 | Zamalek SC | 1-0 | AS Génération Foot | |
| 14.09.2019 | AS Génération Foot | 2-1 | Zamalek SC | |