AS Otôho 1-3 Al Merreikh SC *
| 04.12.2020 | Al Merreikh SC | 2-0 | AS Otôho | |
| 29.11.2020 | AS Otôho | 1-1 | Al Merreikh SC | |
Armed Forces FC 1-3 Teungueth FC *
| 06.12.2020 | Teungueth FC | 2-0 | Armed Forces FC | |
| 29.11.2020 | Armed Forces FC | 1-1 | Teungueth FC | |
*AS SONIDEB 4-0 Mogadishu City
| 05.12.2020 | Mogadishu City | 0-2 | AS SONIDEB | |
| 29.11.2020 | AS SONIDEB | 2-0 | Mogadishu City | |
FC Nouadhibou 1-3 Asante Kotoko *
| 06.12.2020 | Asante Kotoko | 2-0 W.O. | FC Nouadhibou | |
| 29.11.2020 | FC Nouadhibou | 1-1 | Asante Kotoko | |
*Gazelle N'Djamena 4-0 CF GR/SIAF
| 04.12.2020 | CF GR/SIAF | 0-2 W.O. | Gazelle N'Djamena | |
| 29.11.2020 | Gazelle N'Djamena | 2-0 W.O. | CF GR/SIAF | |
*CR Belouizdad 4-0 Nasr Benghazi
| 06.12.2020 | Nasr Benghazi | 0-2 | CR Belouizdad | |
| 29.11.2020 | CR Belouizdad | 2-0 | Nasr Benghazi | |
Mlandege FC 1-8 CS Sfaxien *
| 05.12.2020 | CS Sfaxien | 3-1 | Mlandege FC | |
| 28.11.2020 | Mlandege FC | 0-5 | CS Sfaxien | |
Rahimo FC 1-2 Enyimba FC *
| 06.12.2020 | Enyimba FC | 1-1 | Rahimo FC | |
| 29.11.2020 | Rahimo FC | 0-1 | Enyimba FC | |
Costa do Sol Maputo 1-4 FC Platinum (ZIM) *
| 05.12.2020 | FC Platinum (ZIM) | 2-0 | Costa do Sol Maputo | |
| 28.11.2020 | Costa do Sol Maputo | 1-2 | FC Platinum (ZIM) | |
Forest Rangers 0-2 Bouenguidi Sports *
| 05.12.2020 | Bouenguidi Sports | 2-0 | Forest Rangers | |
| 28.11.2020 | Forest Rangers | 0-0 | Bouenguidi Sports | |
*Jwaneng Galaxy 5-1 US Zilimadjou
| 06.12.2020 | US Zilimadjou | 1-1 | Jwaneng Galaxy | |
| 28.11.2020 | Jwaneng Galaxy | 4-0 | US Zilimadjou | |
PWD Bamenda 0-1 Kaizer Chiefs *
| 05.12.2020 | Kaizer Chiefs | 0-0 | PWD Bamenda | |
| 29.11.2020 | PWD Bamenda | 0-1 | Kaizer Chiefs | |
*Young Buffaloes 1-1 Le Messager Ngozi
| 06.12.2020 | Le Messager Ngozi | 1-1 | Young Buffaloes | |
| 29.11.2020 | Young Buffaloes | 0-0 | Le Messager Ngozi | |
Buffles du Borgou 2-6 MC Alger *
| 19.12.2020 | MC Alger | 5-1 | Buffles du Borgou | |
| 28.11.2020 | Buffles du Borgou | 1-1 | MC Alger | |
*Al Ahli Benghazi 4-0 Mekelle 70
| 05.12.2020 | Mekelle 70 | 0-2 W.O. | Al Ahli Benghazi | |
| 28.11.2020 | Al Ahli Benghazi | 2-0 W.O. | Mekelle 70 | |
Akonangui 2-3 Petro Atlético Luanda *
| 05.12.2020 | Petro Atlético Luanda | 2-2 | Akonangui | |
| 29.11.2020 | Akonangui | 0-1 | Petro Atlético Luanda | |
*RC Abidjan 2-2 ASKO Kara
| 06.12.2020 | ASKO Kara | 2-1 | RC Abidjan | |
| 29.11.2020 | RC Abidjan | 1-0 | ASKO Kara | |
Plateau United 0-1 Simba SC *
| 05.12.2020 | Simba SC | 0-0 | Plateau United | |
| 29.11.2020 | Plateau United | 0-1 | Simba SC | |
Ashanti Golden Boys 1-4 Stade Malien *
| 05.12.2020 | Stade Malien | 2-0 W.O. | Ashanti Golden Boys | |
| 29.11.2020 | Ashanti Golden Boys | 1-2 | Stade Malien | |
Vipers SC 0-2 Al Hilal Al Sudani *
| 06.12.2020 | Al Hilal Al Sudani | 1-0 | Vipers SC | |
| 28.11.2020 | Vipers SC | 0-1 | Al Hilal Al Sudani | |