*Kaizer Chiefs 1-0 1º de Agosto
| 05.01.2021 | 1º de Agosto | 0-1 | Kaizer Chiefs | |
| 23.12.2020 | Kaizer Chiefs | 0-0 | 1º de Agosto | |
Al Ahli Benghazi 2-3 Esperance ST *
| 06.01.2021 | Esperance ST | 3-2 | Al Ahli Benghazi | |
| 23.12.2020 | Al Ahli Benghazi | 0-0 | Esperance ST | |
AS SONIDEB 0-5 Al Ahly Cairo *
| 05.01.2021 | Al Ahly Cairo | 4-0 | AS SONIDEB | |
| 23.12.2020 | AS SONIDEB | 0-1 | Al Ahly Cairo | |
Asante Kotoko 0-3 Al Hilal Al Sudani *
| 06.01.2021 | Al Hilal Al Sudani | 2-0 W.O. | Asante Kotoko | |
| 23.12.2020 | Asante Kotoko | 0-1 | Al Hilal Al Sudani | |
Young Buffaloes 3-6 AS Vita Club *
| 06.01.2021 | AS Vita Club | 4-1 | Young Buffaloes | |
| 22.12.2020 | Young Buffaloes | 2-2 | AS Vita Club | |
Bouenguidi Sports 2-4 TP Mazembe *
| 06.01.2021 | TP Mazembe | 2-1 | Bouenguidi Sports | |
| 23.12.2020 | Bouenguidi Sports | 1-2 | TP Mazembe | |
*CR Belouizdad 8-1 Gor Mahia
| 06.01.2021 | Gor Mahia | 1-2 | CR Belouizdad | |
| 26.12.2020 | CR Belouizdad | 6-0 | Gor Mahia | |
*Al Merreikh SC 4-2 Enyimba FC
| 06.01.2021 | Enyimba FC | 2-1 | Al Merreikh SC | |
| 23.12.2020 | Al Merreikh SC | 3-0 | Enyimba FC | |
RC Abidjan 1-2 Horoya AC *
| 06.01.2021 | Horoya AC | 1-0 | RC Abidjan | |
| 23.12.2020 | RC Abidjan | 1-1 | Horoya AC | |
Jwaneng Galaxy 1-5 Mamelodi Sundowns *
| 05.01.2021 | Mamelodi Sundowns | 3-1 | Jwaneng Galaxy | |
| 22.12.2020 | Jwaneng Galaxy | 0-2 | Mamelodi Sundowns | |
*MC Alger 2-1 CS Sfaxien
| 06.01.2021 | CS Sfaxien | 1-0 | MC Alger | |
| 28.12.2020 | MC Alger | 2-0 | CS Sfaxien | |
Nkana FC 1-2 Petro Atlético Luanda *
| 06.01.2021 | Petro Atlético Luanda | 1-0 | Nkana FC | |
| 23.12.2020 | Nkana FC | 1-1 | Petro Atlético Luanda | |
FC Platinum (ZIM) 1-4 Simba SC *
| 06.01.2021 | Simba SC | 4-0 | FC Platinum (ZIM) | |
| 23.12.2020 | FC Platinum (ZIM) | 1-0 | Simba SC | |
Stade Malien 1-3 Wydad Casablanca *
| 06.01.2021 | Wydad Casablanca | 3-0 | Stade Malien | |
| 23.12.2020 | Stade Malien | 1-0 | Wydad Casablanca | |
*Teungueth FC 0-0 Raja Casablanca
| 05.01.2021 | Raja Casablanca | 0-0/p.1-3 | Teungueth FC | |
| 22.12.2020 | Teungueth FC | 0-0 | Raja Casablanca | |
Gazelle N'Djamena 0-4 Zamalek SC *
| 06.01.2021 | Zamalek SC | 2-0 W.O. | Gazelle N'Djamena | |
| 23.12.2020 | Gazelle N'Djamena | 0-2 W.O. | Zamalek SC | |