*Ahly Cairo 3-1 Mamelodi Sundowns
| 22.05.2021 | Mamelodi Sundowns | 1-1 | Ahly Cairo | |
| 15.05.2021 | Ahly Cairo | 2-0 | Mamelodi Sundowns | |
CR Belouizdad 2-2 Esperance ST *
| 22.05.2021 | Esperance ST | 2-0/p.3-2 | CR Belouizdad | |
| 15.05.2021 | CR Belouizdad | 2-0 | Esperance ST | |
*Kaizer Chiefs 4-3 Simba SC
| 22.05.2021 | Simba SC | 3-0 | Kaizer Chiefs | |
| 15.05.2021 | Kaizer Chiefs | 4-0 | Simba SC | |
MC Alger 1-2 Wydad Casablanca *
| 22.05.2021 | Wydad Casablanca | 1-0 | MC Alger | |
| 14.05.2021 | MC Alger | 1-1 | Wydad Casablanca | |