*Ahly Cairo 3-2 Raja Casablanca
| 23.04.2022 | Raja Casablanca | 1-1 | Ahly Cairo | |
| 16.04.2022 | Ahly Cairo | 2-1 | Raja Casablanca | |
CR Belouizdad 0-1 Wydad Casablanca *
| 24.04.2022 | Wydad Casablanca | 0-0 | CR Belouizdad | |
| 16.04.2022 | CR Belouizdad | 0-1 | Wydad Casablanca | |
*ES Sétif 1-0 Esperance ST
| 22.04.2022 | Esperance ST | 0-1 | ES Sétif | |
| 15.04.2022 | ES Sétif | 0-0 | Esperance ST | |
*Petro Atlético Luanda 3-2 Mamelodi Sundowns
| 23.04.2022 | Mamelodi Sundowns | 1-1 | Petro Atlético Luanda | |
| 16.04.2022 | Petro Atlético Luanda | 2-1 | Mamelodi Sundowns | |