Saint George SA 2-2 Al Hilal Al Sudani *
| 18.09.2022 | Al Hilal Al Sudani | 1-0 | Saint George SA | |
| 11.09.2022 | Saint George SA | 2-1 | Al Hilal Al Sudani | |
APR FC 1-3 US Monastir *
| 18.09.2022 | US Monastir | 3-0 | APR FC | |
| 10.09.2022 | APR FC | 1-0 | US Monastir | |
AS Stade Mandji 2-3 Plateau United *
| 18.09.2022 | Plateau United | 1-0 | AS Stade Mandji | |
| 10.09.2022 | AS Stade Mandji | 2-2 | Plateau United | |
*Rail Club Kadiogo 1-1 Asante Kotoko
| 18.09.2022 | Asante Kotoko | 0-1/p.1-3 | Rail Club Kadiogo | |
| 12.09.2022 | Rail Club Kadiogo | 0-1 | Asante Kotoko | |
*Cape Town City 2-0 AS Otôho
| 18.09.2022 | AS Otôho | 0-0 | Cape Town City | |
| 10.09.2022 | Cape Town City | 2-0 | AS Otôho | |
Casa Sport 1-3 JS Kabylie *
| 18.09.2022 | JS Kabylie | 3-0 | Casa Sport | |
| 11.09.2022 | Casa Sport | 1-0 | JS Kabylie | |
CFF Analamanga 3-5 Royal Leopards *
| 17.09.2022 | Royal Leopards | 2-1 | CFF Analamanga | |
| 11.09.2022 | CFF Analamanga | 2-3 | Royal Leopards | |
Coton de Ouidah 1-4 ASEC Mimosas *
| 18.09.2022 | ASEC Mimosas | 2-0 | Coton de Ouidah | |
| 11.09.2022 | Coton de Ouidah | 1-2 | ASEC Mimosas | |
Matlama FC 0-4 Coton Sport *
| 18.09.2022 | Coton Sport | 1-0 | Matlama FC | |
| 10.09.2022 | Matlama FC | 0-3 | Coton Sport | |
Bo Rangers FC 0-3 CR Belouizdad *
| 17.09.2022 | CR Belouizdad | 3-0 | Bo Rangers FC | |
| 10.09.2022 | Bo Rangers FC | 0-0 | CR Belouizdad | |
Deportivo Mongomo 2-5 Djoliba AC *
| 19.09.2022 | Djoliba AC | 5-0 | Deportivo Mongomo | |
| 10.09.2022 | Deportivo Mongomo | 2-0 | Djoliba AC | |
*ASKO Kara 2-1 FC Nouadhibou
| 17.09.2022 | FC Nouadhibou | 0-1 | ASKO Kara | |
| 11.09.2022 | ASKO Kara | 1-1 | FC Nouadhibou | |
*Flambeau du Centre 2-2 Ittihad Tripoli
| 18.09.2022 | Ittihad Tripoli | 2-1 | Flambeau du Centre | |
| 11.09.2022 | Flambeau du Centre | 1-0 | Ittihad Tripoli | |
Gaborone United 2-3 AS Vita Club *
| 18.09.2022 | AS Vita Club | 3-1 | Gaborone United | |
| 11.09.2022 | Gaborone United | 1-0 | AS Vita Club | |
Banjul Hawks 0-6 Horoya AC *
| 16.09.2022 | Horoya AC | 3-0 W.O. | Banjul Hawks | |
| 09.09.2022 | Banjul Hawks | 0-3 W.O. | Horoya AC | |
KMKM 0-6 Al Ahli Tripoli *
| 17.09.2022 | Al Ahli Tripoli | 4-0 | KMKM | |
| 10.09.2022 | KMKM | 0-2 | Al Ahli Tripoli | |
AS Arta 1-2 Merreikh Al Sudan *
| 17.09.2022 | Merreikh Al Sudan | 0-0 | AS Arta | |
| 11.09.2022 | AS Arta | 1-2 | Merreikh Al Sudan | |
Olympic Real Bangui 0-4 Vipers SC *
| 17.09.2022 | Vipers SC | 1-0 | Olympic Real Bangui | |
| 10.09.2022 | Olympic Real Bangui | 0-3 | Vipers SC | |
Black Bulls 1-5 Petro Atlético Luanda *
| 17.09.2022 | Petro Atlético Luanda | 2-1 | Black Bulls | |
| 11.09.2022 | Black Bulls | 0-3 | Petro Atlético Luanda | |
Red Arrows FC 1-2 1º de Agosto *
| 18.09.2022 | 1º de Agosto | 1-1 | Red Arrows FC | |
| 10.09.2022 | Red Arrows FC | 0-1 | 1º de Agosto | |
*Rivers United 3-1 Watanga FC
| 18.09.2022 | Watanga FC | 1-0 | Rivers United | |
| 11.09.2022 | Rivers United | 3-0 | Watanga FC | |
Nyasa Big Bullets 0-4 Simba SC *
| 18.09.2022 | Simba SC | 2-0 | Nyasa Big Bullets | |
| 10.09.2022 | Nyasa Big Bullets | 0-2 | Simba SC | |
*AS NIGELEC 2-1 SOA Renaissante
| 16.09.2022 | SOA Renaissante | 0-0 | AS NIGELEC | |
| 10.09.2022 | AS NIGELEC | 2-1 | SOA Renaissante | |
Volcan Club 1-3 La Passe FC *
| 16.09.2022 | La Passe FC | 3-0 W.O. | Volcan Club | |
| 10.09.2022 | Volcan Club | 1-0 | La Passe FC | |
Zalan FC 0-9 Young Africans *
| 17.09.2022 | Young Africans | 5-0 | Zalan FC | |
| 10.09.2022 | Zalan FC | 0-4 | Young Africans | |
Elect Sport FC 0-4 Zamalek SC *
| 25.09.2022 | Zamalek SC | 2-0 | Elect Sport FC | |
| 18.09.2022 | Elect Sport FC | 0-2 | Zamalek SC | |