US Monastir 0-4 Al Ahly Cairo *
| 15.10.2022 | Al Ahly Cairo | 3-0 | US Monastir | |
| 09.10.2022 | US Monastir | 0-1 | Al Ahly Cairo | |
*Al Merreikh SC 3-3 Al Ahli Tripoli
| 15.10.2022 | Al Ahli Tripoli | 3-1 | Al Merreikh SC | |
| 07.10.2022 | Al Merreikh SC | 2-0 | Al Ahli Tripoli | |
AS NIGELEC 0-3 Raja Casablanca *
| 15.10.2022 | Raja Casablanca | 1-0 | AS NIGELEC | |
| 08.10.2022 | AS NIGELEC | 0-2 | Raja Casablanca | |
ASKO Kara 2-3 JS Kabylie *
| 15.10.2022 | JS Kabylie | 1-1 | ASKO Kara | |
| 08.10.2022 | ASKO Kara | 1-2 | JS Kabylie | |
Cape Town City 0-4 Petro Atlético Luanda *
| 14.10.2022 | Petro Atlético Luanda | 1-0 | Cape Town City | |
| 08.10.2022 | Cape Town City | 0-3 | Petro Atlético Luanda | |
Djoliba AC 2-3 CR Belouizdad *
| 14.10.2022 | CR Belouizdad | 2-0 | Djoliba AC | |
| 09.10.2022 | Djoliba AC | 2-1 | CR Belouizdad | |
ASEC Mimosas 1-2 Horoya AC *
| 16.10.2022 | Horoya AC | 1-1 | ASEC Mimosas | |
| 09.10.2022 | ASEC Mimosas | 0-1 | Horoya AC | |
La Passe FC 1-15 Mamelodi Sundowns *
| 14.10.2022 | Mamelodi Sundowns | 8-1 | La Passe FC | |
| 09.10.2022 | La Passe FC | 0-7 | Mamelodi Sundowns | |
Plateau United 2-2 Esperance ST *
| 15.10.2022 | Esperance ST | 1-0 | Plateau United | |
| 09.10.2022 | Plateau United | 2-1 | Esperance ST | |
Rail Club Kadiogo 0-0 AS Vita Club *
| 20.10.2022 | AS Vita Club | 0-0/p.4-3 | Rail Club Kadiogo | |
| 16.10.2022 | Rail Club Kadiogo | 0-0 | AS Vita Club | |
Rivers United 2-7 Wydad Casablanca *
| 16.10.2022 | Wydad Casablanca | 6-0 | Rivers United | |
| 09.10.2022 | Rivers United | 2-1 | Wydad Casablanca | |
Royal Leopards 2-3 Coton Sport *
| 16.10.2022 | Coton Sport | 2-1 | Royal Leopards | |
| 09.10.2022 | Royal Leopards | 1-1 | Coton Sport | |
1º de Agosto 1-4 Simba SC *
| 16.10.2022 | Simba SC | 1-0 | 1º de Agosto | |
| 09.10.2022 | 1º de Agosto | 1-3 | Simba SC | |
*Vipers SC 0-0 TP Mazembe
| 15.10.2022 | TP Mazembe | 0-0/p.2-4 | Vipers SC | |
| 09.10.2022 | Vipers SC | 0-0 | TP Mazembe | |
Young Africans 1-2 Al Hilal Omdurman *
| 16.10.2022 | Al Hilal Omdurman | 1-0 | Young Africans | |
| 08.10.2022 | Young Africans | 1-1 | Al Hilal Omdurman | |
Flambeau du Centre 1-6 Zamalek SC *
| 14.10.2022 | Zamalek SC | 5-1 | Flambeau du Centre | |
| 09.10.2022 | Flambeau du Centre | 0-1 | Zamalek SC | |