Gor Mahia 0-6 Al Ahly Cairo *
| 21.09.2024 | Al Ahly Cairo | 3-0 | Gor Mahia | |
| 15.09.2024 | Gor Mahia | 0-3 | Al Ahly Cairo | |
AS Douanes (BFA) 1-1 CR Belouizdad *
| 20.09.2024 | CR Belouizdad | 1-0/p.4-3 | AS Douanes (BFA) | |
| 14.09.2024 | AS Douanes (BFA) | 1-0 | CR Belouizdad | |
*AS Maniema Union 2-1 Petro Atlético Luanda
| 21.09.2024 | Petro Atlético Luanda | 0-0 | AS Maniema Union | |
| 14.09.2024 | AS Maniema Union | 2-1 | Petro Atlético Luanda | |
CBE SA 0-7 Young Africans *
| 21.09.2024 | Young Africans | 6-0 | CBE SA | |
| 14.09.2024 | CBE SA | 0-1 | Young Africans | |
Dekedaha FC 1-12 Esperance ST *
| 21.09.2024 | Esperance ST | 8-0 | Dekedaha FC | |
| 15.09.2024 | Dekedaha FC | 1-4 | Esperance ST | |
*Djoliba AC 2-0 ASKO Kara
| 22.09.2024 | ASKO Kara | 0-1 | Djoliba AC | |
| 14.09.2024 | Djoliba AC | 1-0 | ASKO Kara | |
Enugu Rangers 2-3 Sagrada Esperanca *
| 22.09.2024 | Sagrada Esperanca | 3-1 | Enugu Rangers | |
| 13.09.2024 | Enugu Rangers | 1-0 | Sagrada Esperanca | |
Al Merreikh SC 2-4 FAR Rabat *
| 22.09.2024 | FAR Rabat | 2-0 | Al Merreikh SC | |
| 14.09.2024 | Al Merreikh SC | 2-2 | FAR Rabat | |
FC Samartex 1996 2-4 Raja Casablanca *
| 21.09.2024 | Raja Casablanca | 2-0 | FC Samartex 1996 | |
| 15.09.2024 | FC Samartex 1996 | 2-2 | Raja Casablanca | |
FC San Pédro 2-3 Al Hilal Omdurman *
| 22.09.2024 | Al Hilal Omdurman | 1-0 | FC San Pédro | |
| 15.09.2024 | FC San Pédro | 2-2 | Al Hilal Omdurman | |
Mbabane Swallows 0-8 Mamelodi Sundowns *
| 21.09.2024 | Mamelodi Sundowns | 4-0 | Mbabane Swallows | |
| 14.09.2024 | Mbabane Swallows | 0-4 | Mamelodi Sundowns | |
US Monastir 1-2 MC Alger *
| 21.09.2024 | MC Alger | 2-0 | US Monastir | |
| 13.09.2024 | US Monastir | 1-0 | MC Alger | |
Jwaneng Galaxy 0-3 Orlando Pirates *
| 21.09.2024 | Orlando Pirates | 1-0 | Jwaneng Galaxy | |
| 14.09.2024 | Jwaneng Galaxy | 0-2 | Orlando Pirates | |
APR FC 2-4 Pyramids FC *
| 21.09.2024 | Pyramids FC | 3-1 | APR FC | |
| 14.09.2024 | APR FC | 1-1 | Pyramids FC | |
Red Arrows FC 1-4 TP Mazembe *
| 21.09.2024 | TP Mazembe | 2-1 | Red Arrows FC | |
| 14.09.2024 | Red Arrows FC | 0-2 | TP Mazembe | |
*Stade d'Abidjan 3-2 Milo FC
| 22.09.2024 | Milo FC | 2-1 | Stade d'Abidjan | |
| 15.09.2024 | Stade d'Abidjan | 2-0 | Milo FC | |