Ajax Cape Town 5-6 Mount Cameroon FC *
| 11.05.2008 | Mount Cameroon FC | 5-0 | Ajax Cape Town | |
| 27.04.2008 | Ajax Cape Town | 5-1 | Mount Cameroon FC | |
Al Akhdar SC 1-2 Haras Al Hodoud *
| 10.05.2008 | Haras Al Hodoud | 1-0 | Al Akhdar SC | |
| 25.04.2008 | Al Akhdar SC | 1-1 | Haras Al Hodoud | |
Highlanders FC 1-5 Al Merreikh SC *
| 11.05.2008 | Al Merreikh SC | 3-1 | Highlanders FC | |
| 26.04.2008 | Highlanders FC | 0-2 | Al Merreikh SC | |
ASC Linguère 4-4 CS Sfaxien *
| 10.05.2008 | CS Sfaxien | 2-1 | ASC Linguère | |
| 26.04.2008 | ASC Linguère | 3-2 | CS Sfaxien | |
*Djoliba AC 5-2 AS Mangasport
| 11.05.2008 | AS Mangasport | 1-2 | Djoliba AC | |
| 27.04.2008 | Djoliba AC | 3-1 | AS Mangasport | |
Dolphins FC PH 3-4 Asante Kotoko *
| 11.05.2008 | Asante Kotoko | 4-1 | Dolphins FC PH | |
| 27.04.2008 | Dolphins FC PH | 2-0 | Asante Kotoko | |
US Masséda 2-6 Esperance ST *
| 10.05.2008 | Esperance ST | 6-1 | US Masséda | |
| 27.04.2008 | US Masséda | 1-0 | Esperance ST | |
*Les Astres FC 1-1 AS Vita Club
| 09.05.2008 | AS Vita Club | 1-1 | Les Astres FC | |
| 27.04.2008 | Les Astres FC | 0-0 | AS Vita Club | |