*AC Léopard 3-1 Etincelles FC
| 12.02.2011 | Etincelles FC | 0-2 | AC Léopard | |
| 29.01.2011 | AC Léopard | 1-1 | Etincelles FC | |
*AS Adema 1-1 CD Maxaquene
| 13.02.2011 | CD Maxaquene | 1-1 | AS Adema | |
| 30.01.2011 | AS Adema | 0-0 | CD Maxaquene | |
*Missile FC 4-1 AS Inter Star
| 27.02.2011 | AS Inter Star | 1-0 | Missile FC | |
| 29.01.2011 | Missile FC | 4-0 | AS Inter Star | |
ASA Luanda 0-0 Sofapaka Nairobi *
| 13.02.2011 | Sofapaka Nairobi | 0-0/p.5-4 | ASA Luanda | |
| 30.01.2011 | ASA Luanda | 0-0 | Sofapaka Nairobi | |
CA Batna 4-4 Nasr Benghazi *
| 11.02.2011 | Nasr Benghazi | 2-2/p.6-5 | CA Batna | |
| 28.01.2011 | CA Batna | 2-2 | Nasr Benghazi | |
*Foullah Edifice 2-1 CD Elá Nguema
| 11.02.2011 | CD Elá Nguema | 1-0 | Foullah Edifice | |
| 30.01.2011 | Foullah Edifice | 2-0 | CD Elá Nguema | |
Centre Salif Keita 3-3 Difaâ El Jadidi *
| 12.02.2011 | Difaâ El Jadidi | 1-1 | Centre Salif Keita | |
| 30.01.2011 | Centre Salif Keita | 2-2 | Difaâ El Jadidi | |
DYTO Lomé 0-0 Sahel SC Niamey *
| 27.02.2011 | Sahel SC Niamey | 0-0/p.4-2 | DYTO Lomé | |
| 30.01.2011 | DYTO Lomé | 0-0 | Sahel SC Niamey | |
FC Séquence 0-1 Africa Sports
| 28.01.2011 | FC Séquence | 0-1 | Africa Sports | |
*FC Tevragh-Zeina 1-0 AS Real Bamako
| 26.02.2011 | AS Real Bamako | 0-1 | FC Tevragh-Zeina | |
| 29.01.2011 | FC Tevragh-Zeina | 0-0 | AS Real Bamako | |
Fovu Baham 3-4 US Forces Armées *
| 13.02.2011 | US Forces Armées | 3-1 | Fovu Baham | |
| 29.01.2011 | Fovu Baham | 2-1 | US Forces Armées | |
Highlanders FC 1-4 Nchanga Rangers *
| 11.02.2011 | Nchanga Rangers | 3-0 W.O. | Highlanders FC | |
| 29.01.2011 | Highlanders FC | 1-1 | Nchanga Rangers | |
KMKM 0-6 DC Motema Pembe *
| 25.02.2011 | DC Motema Pembe | 2-0 | KMKM | |
| 29.01.2011 | KMKM | 0-4 | DC Motema Pembe | |
Séwé Sports 0-2 Ashanti Gold SC *
| 27.02.2011 | Ashanti Gold SC | 1-0 | Séwé Sports | |
| 29.01.2011 | Séwé Sports | 0-1 | Ashanti Gold SC | |
*SO Armée 1-1 FC Séquence
| 26.02.2011 | SO Armée | 1-1 | FC Séquence | |
Diplomates FC 8ème Arr. 1-3 Tiko United *
| 12.02.2011 | Tiko United | 3-1 | Diplomates FC 8ème Arr. | |
| 29.01.2011 | Diplomates FC 8ème Arr. | 0-0 | Tiko United | |
*Toure Kunda Footpro 4-3 Ports Auth. Freetown
| 12.02.2011 | Ports Auth. Freetown | 2-2 | Toure Kunda Footpro | |
| 29.01.2011 | Toure Kunda Footpro | 2-1 | Ports Auth. Freetown | |
US Sainte-Marienne 1-4 Bidvest Wits *
| 12.02.2011 | Bidvest Wits | 4-0 | US Sainte-Marienne | |
| 29.01.2011 | US Sainte-Marienne | 1-0 | Bidvest Wits | |
USS Kraké 2-5 Maghreb Fès *
| 11.02.2011 | Maghreb Fès | 4-1 | USS Kraké | |
| 29.01.2011 | USS Kraké | 1-1 | Maghreb Fès | |
Mbabane Highlanders 2-2 Victors Kampala *
| 11.02.2011 | Victors Kampala | 1-1/p.4-1 | Mbabane Highlanders | |
| 29.01.2011 | Mbabane Highlanders | 1-1 | Victors Kampala | |
Young Africans 4-6 Dedebit FC *
| 12.02.2011 | Dedebit FC | 2-0 | Young Africans | |
| 29.01.2011 | Young Africans | 4-4 | Dedebit FC | |