*AC Léopard 4-2 AS Tempête Mocaf
| 04.03.2012 | AS Tempête Mocaf | 2-2 | AC Léopard | |
| 19.02.2012 | AC Léopard | 2-0 | AS Tempête Mocaf | |
AS Dragons (BEN) 0-3 Étoile Filante *
| 03.03.2012 | Étoile Filante | 2-0 | AS Dragons (BEN) | |
| 19.02.2012 | AS Dragons (BEN) | 0-1 | Étoile Filante | |
AS Mangasport 0-5 Saint George SA *
| 03.03.2012 | Saint George SA | 4-0 | AS Mangasport | |
| 18.02.2012 | AS Mangasport | 0-1 | Saint George SA | |
*LLB S4 Africa 5-0 Atlético Semu
| 03.03.2012 | Atlético Semu | 0-2 | LLB S4 Africa | |
| 19.02.2012 | LLB S4 Africa | 3-0 | Atlético Semu | |
*Black Leopards 3-1 Motor Action FC
| 04.03.2012 | Motor Action FC | 0-2 | Black Leopards | |
| 18.02.2012 | Black Leopards | 1-1 | Motor Action FC | |
*GAMTEL FC 1-1 Casa Sport
| 04.03.2012 | Casa Sport | 1-0/p.3-4 | GAMTEL FC | |
| 19.02.2012 | GAMTEL FC | 1-0 | Casa Sport | |
Union Douala 1-2 FC Kallon *
| 03.03.2012 | FC Kallon | 2-0 | Union Douala | |
| 18.02.2012 | Union Douala | 1-0 | FC Kallon | |
*Ferroviário Maputo 4-0 Gor Mahia
| 10.03.2012 | Gor Mahia | 0-1 | Ferroviário Maputo | |
| 18.02.2012 | Ferroviário Maputo | 3-0 | Gor Mahia | |
ADR Desportivo 0-6 Invincible Eleven
| 02.03.2012 | Invincible Eleven | 3-0 W.O. | ADR Desportivo | |
| 18.02.2012 | ADR Desportivo | 0-3 W.O. | Invincible Eleven | |
Jamhuri FC 1-7 Hwange Colliery *
| 04.03.2012 | Hwange Colliery | 4-1 | Jamhuri FC | |
| 18.02.2012 | Jamhuri FC | 0-3 | Hwange Colliery | |
Nania FC 0-6 FC Séquence
| 02.03.2012 | FC Séquence | 3-0 W.O. | Nania FC | |
| 18.02.2012 | Nania FC | 0-3 W.O. | FC Séquence | |
Red Arrows FC 0-1 Royal Leopards *
| 03.03.2012 | Royal Leopards | 1-0 | Red Arrows FC | |
| 18.02.2012 | Red Arrows FC | 0-0 | Royal Leopards | |
*Renaissance (CHA) 4-2 Sahel SC Niamey
| 04.03.2012 | Sahel SC Niamey | 2-2 | Renaissance (CHA) | |
| 19.02.2012 | Renaissance (CHA) | 2-0 | Sahel SC Niamey | |
Séwé Sports 0-1 Unisport Bafang *
| 03.03.2012 | Unisport Bafang | 0-0 | Séwé Sports | |
| 18.02.2012 | Séwé Sports | 0-1 | Unisport Bafang | |
Kiyovu Sports 2-3 Simba SC *
| 04.03.2012 | Simba SC | 2-1 | Kiyovu Sports | |
| 18.02.2012 | Kiyovu Sports | 1-1 | Simba SC | |
Extension Gunners 2-3 Tana FC Formation *
| 04.03.2012 | Tana FC Formation | 2-0 | Extension Gunners | |
| 18.02.2012 | Extension Gunners | 2-1 | Tana FC Formation | |