*AC Léopard 3-2 CS Sfaxien
| 07.04.2012 | CS Sfaxien | 0-2 | AC Léopard | |
| 25.03.2012 | AC Léopard | 1-2 | CS Sfaxien | |
Ferroviário Maputo 0-3 Ahli Shandi *
| 08.04.2012 | Ahli Shandi | 2-0 | Ferroviário Maputo | |
| 24.03.2012 | Ferroviário Maputo | 0-1 | Ahli Shandi | |
Hwange Colliery 1-1 Al Amal Atbara *
| 08.04.2012 | Al Amal Atbara | 0-0 | Hwange Colliery | |
| 25.03.2012 | Hwange Colliery | 1-1 | Al Amal Atbara | |
*Black Leopards 6-4 Saint Eloi Lupopo
| 06.04.2012 | Saint Eloi Lupopo | 2-2 | Black Leopards | |
| 24.03.2012 | Black Leopards | 4-2 | Saint Eloi Lupopo | |
Étoile Filante 2-4 ASEC Mimosas *
| 06.04.2012 | ASEC Mimosas | 2-0 | Étoile Filante | |
| 24.03.2012 | Étoile Filante | 2-2 | ASEC Mimosas | |
FC Kallon 0-2 Warri Wolves *
| 06.04.2012 | Warri Wolves | 2-0 | FC Kallon | |
| 24.03.2012 | FC Kallon | 0-0 | Warri Wolves | |
FC Séquence 0-5 CODM Meknès *
| 08.04.2012 | CODM Meknès | 3-0 | FC Séquence | |
| 23.03.2012 | FC Séquence | 0-2 | CODM Meknès | |
GAMTEL FC 2-3 AS Real Bamako
| 09.04.2012 | AS Real Bamako | 3-1 | GAMTEL FC | |
| 25.03.2012 | GAMTEL FC | 1-0 | AS Real Bamako | |
Unisport Bafang 1-2 Heartland FC *
| 08.04.2012 | Heartland FC | 2-1 | Unisport Bafang | |
| 24.03.2012 | Unisport Bafang | 0-0 | Heartland FC | |
LLB S4 Africa 2-5 ENPPI Cairo *
| 07.04.2012 | ENPPI Cairo | 4-1 | LLB S4 Africa | |
| 24.03.2012 | LLB S4 Africa | 1-1 | ENPPI Cairo | |
Renaissance (CHA) 4-5 Cercle Olympique *
| 06.04.2012 | Cercle Olympique | 3-1 | Renaissance (CHA) | |
| 25.03.2012 | Renaissance (CHA) | 3-2 | Cercle Olympique | |
Saint George SA 1-3 Club Africain Tunis *
| 07.04.2012 | Club Africain Tunis | 2-0 | Saint George SA | |
| 24.03.2012 | Saint George SA | 1-1 | Club Africain Tunis | |
Tana FC Formation 2-2 Interclube Luanda *
| 08.04.2012 | Interclube Luanda | 2-0/p.6-5 | Tana FC Formation | |
| 25.03.2012 | Tana FC Formation | 2-0 | Interclube Luanda | |
*Royal Leopards 3-2 US Tshinkunku
| 07.04.2012 | US Tshinkunku | 1-2 | Royal Leopards | |
| 24.03.2012 | Royal Leopards | 1-1 | US Tshinkunku | |
Invincible Eleven 1-6 Wydad Casablanca *
| 07.04.2012 | Wydad Casablanca | 4-1 | Invincible Eleven | |
| 24.03.2012 | Invincible Eleven | 0-2 | Wydad Casablanca | |