Heartland FC 4-4 AC Léopard *
| 13.05.2012 | AC Léopard | 2-1 | Heartland FC | |
| 29.04.2012 | Heartland FC | 3-2 | AC Léopard | |
Simba SC 3-3 Ahli Shandi *
| 13.05.2012 | Ahli Shandi | 3-0/p.9-8 | Simba SC | |
| 29.04.2012 | Simba SC | 3-0 | Ahli Shandi | |
*Interclube Luanda 6-1 Al Amal Atbara
| 13.05.2012 | Al Amal Atbara | 0-2 | Interclube Luanda | |
| 29.04.2012 | Interclube Luanda | 4-1 | Al Amal Atbara | |
ASEC Mimosas 1-1 CODM Meknès *
| 13.05.2012 | CODM Meknès | 0-0 | ASEC Mimosas | |
| 28.04.2012 | ASEC Mimosas | 1-1 | CODM Meknès | |
Warri Wolves 3-3 Black Leopards *
| 13.05.2012 | Black Leopards | 2-0 | Warri Wolves | |
| 29.04.2012 | Warri Wolves | 3-1 | Black Leopards | |
ENPPI Cairo 3-4 Cercle Olympique *
| 13.05.2012 | Cercle Olympique | 3-0 | ENPPI Cairo | |
| 27.04.2012 | ENPPI Cairo | 3-1 | Cercle Olympique | |
Royal Leopards 2-5 Club Africain Tunis *
| 12.05.2012 | Club Africain Tunis | 4-2 | Royal Leopards | |
| 28.04.2012 | Royal Leopards | 0-1 | Club Africain Tunis | |
*Wydad Casablanca 3-1 AS Real Bamako
| 12.05.2012 | AS Real Bamako | 1-0 | Wydad Casablanca | |
| 29.04.2012 | Wydad Casablanca | 3-0 | AS Real Bamako | |