*Vita Club Mokanda 1-1 Akwa United
| 27.02.2016 | Akwa United | 0-1/p.5-6 | Vita Club Mokanda | |
| 13.02.2016 | Vita Club Mokanda | 0-1 | Akwa United | |
*Harare City 6-3 AS Adema
| 28.02.2016 | AS Adema | 1-3 | Harare City | |
| 13.02.2016 | Harare City | 3-2 | AS Adema | |
*Ittihad Tripoli 5-4 AS SONIDEB
| 05.03.2016 | AS SONIDEB | 3-1 | Ittihad Tripoli | |
| 12.02.2016 | Ittihad Tripoli | 4-1 | AS SONIDEB | |
*Saint Eloi Lupopo 3-1 Bandari FC
| 28.02.2016 | Bandari FC | 1-1 | Saint Eloi Lupopo | |
| 14.02.2016 | Saint Eloi Lupopo | 2-0 | Bandari FC | |
Defense (ETH) 1-6 Masr lel Maqassah *
| 27.02.2016 | Masr lel Maqassah | 3-0 | Defense (ETH) | |
| 13.02.2016 | Defense (ETH) | 1-3 | Masr lel Maqassah | |
Diables Noirs 2-4 Africa Sports *
| 27.02.2016 | Africa Sports | 2-1 | Diables Noirs | |
| 14.02.2016 | Diables Noirs | 1-2 | Africa Sports | |
Fomboni FC 1-2 Atlético Olympique *
| 27.02.2016 | Atlético Olympique | 2-0 | Fomboni FC | |
| 13.02.2016 | Fomboni FC | 1-0 | Atlético Olympique | |
*JKU FC 6-0 Gaborone United
| 26.02.2016 | Gaborone United | 0-3 W.O. | JKU FC | |
| 14.02.2016 | JKU FC | 3-0 W.O. | Gaborone United | |
Light Stars 0-9 Bidvest Wits *
| 27.02.2016 | Bidvest Wits | 6-0 | Light Stars | |
| 13.02.2016 | Light Stars | 0-3 | Bidvest Wits | |
*Nasarawa Utd 2-1 AS Génération Foot
| 27.02.2016 | AS Génération Foot | 0-0 | Nasarawa Utd | |
| 14.02.2016 | Nasarawa Utd | 2-1 | AS Génération Foot | |
*Renaissance (CHA) 3-2 New Stars de Duala
| 27.02.2016 | New Stars de Duala | 2-2 | Renaissance (CHA) | |
| 13.02.2016 | Renaissance (CHA) | 1-0 | New Stars de Duala | |
*Police FC (RWA) 4-3 Atlabara Juba
| 28.02.2016 | Atlabara Juba | 2-1 | Police FC (RWA) | |
| 13.02.2016 | Police FC (RWA) | 3-1 | Atlabara Juba | |
*Sagrada Esperanca 3-2 Ajax Cape Town
| 27.02.2016 | Ajax Cape Town | 0-2 | Sagrada Esperanca | |
| 13.02.2016 | Sagrada Esperanca | 1-2 | Ajax Cape Town | |
Khartoum Al Watani 0-2 SC Villa *
| 27.02.2016 | SC Villa | 1-0 | Khartoum Al Watani | |
| 13.02.2016 | Khartoum Al Watani | 0-1 | SC Villa | |
AS Bakaridjan 2-2 Stade Gabésien *
| 27.02.2016 | Stade Gabésien | 1-1/p.4-3 | AS Bakaridjan | |
| 12.02.2016 | AS Bakaridjan | 1-1 | Stade Gabésien | |
UMS de Loum 0-0 Deportivo Mongomo *
| 27.02.2016 | Deportivo Mongomo | 0-0/p.4-2 | UMS de Loum | |
| 14.02.2016 | UMS de Loum | 0-0 | Deportivo Mongomo | |
*KAC Marrakech 3-3 US Forces Armées
| 27.02.2016 | US Forces Armées | 3-0/p.4-5 | KAC Marrakech | |
| 14.02.2016 | KAC Marrakech | 3-0 | US Forces Armées | |
*SC Gagnoa 2-0 USFAS Bamako
| 28.02.2016 | USFAS Bamako | 0-0 | SC Gagnoa | |
| 13.02.2016 | SC Gagnoa | 2-0 | USFAS Bamako | |
Wallidan FC 0-6 MC Oran *
| 26.02.2016 | MC Oran | 3-0 W.O. | Wallidan FC | |
| 12.02.2016 | Wallidan FC | 0-3 W.O. | MC Oran | |