Africa Sports 1-6 ENPPI Cairo *
| 20.03.2016 | ENPPI Cairo | 4-1 | Africa Sports | |
| 12.03.2016 | Africa Sports | 0-2 | ENPPI Cairo | |
Saint Eloi Lupopo 2-2 Ahli Shandi *
| 20.03.2016 | Ahli Shandi | 1-0 | Saint Eloi Lupopo | |
| 13.03.2016 | Saint Eloi Lupopo | 2-1 | Ahli Shandi | |
*Stade Gabésien 2-1 AS Kaloum Star
| 18.03.2016 | AS Kaloum Star | 0-0 | Stade Gabésien | |
| 12.03.2016 | Stade Gabésien | 2-1 | AS Kaloum Star | |
Bidvest Wits 3-7 Azam FC *
| 20.03.2016 | Azam FC | 4-3 | Bidvest Wits | |
| 12.03.2016 | Bidvest Wits | 0-3 | Azam FC | |
*KAC Marrakech 3-2 BYC FC
| 20.03.2016 | BYC FC | 2-0 | KAC Marrakech | |
| 12.03.2016 | KAC Marrakech | 3-0 | BYC FC | |
Nasarawa Utd 2-4 CS Constantine *
| 19.03.2016 | CS Constantine | 4-1 | Nasarawa Utd | |
| 13.03.2016 | Nasarawa Utd | 1-0 | CS Constantine | |
Renaissance (CHA) 0-7 Esperance ST *
| 19.03.2016 | Esperance ST | 5-0 | Renaissance (CHA) | |
| 12.03.2016 | Renaissance (CHA) | 0-2 | Esperance ST | |
UMS de Loum 2-3 FUS Rabat *
| 19.03.2016 | FUS Rabat | 2-1 | UMS de Loum | |
| 11.03.2016 | UMS de Loum | 1-1 | FUS Rabat | |
Ittihad Tripoli 1-2 Medeama SC *
| 20.03.2016 | Medeama SC | 2-0 | Ittihad Tripoli | |
| 13.03.2016 | Ittihad Tripoli | 1-0 | Medeama SC | |
*Masr lel Maqassah 3-2 CS Don Bosco
| 19.03.2016 | CS Don Bosco | 1-0 | Masr lel Maqassah | |
| 12.03.2016 | Masr lel Maqassah | 3-1 | CS Don Bosco | |
Atlético Olympique 0-5 Mounana FC *
| 20.03.2016 | Mounana FC | 3-0 | Atlético Olympique | |
| 12.03.2016 | Atlético Olympique | 0-2 | Mounana FC | |
*Sagrada Esperanca 2-1 Liga Muçulmana
| 19.03.2016 | Liga Muçulmana | 1-1 | Sagrada Esperanca | |
| 12.03.2016 | Sagrada Esperanca | 1-0 | Liga Muçulmana | |
*Vita Club Mokanda 1-0 Police FC (RWA)
| 19.03.2016 | Police FC (RWA) | 0-1 | Vita Club Mokanda | |
| 12.03.2016 | Vita Club Mokanda | 0-0 | Police FC (RWA) | |
Harare City 2-5 Zanaco FC *
| 20.03.2016 | Zanaco FC | 3-1 | Harare City | |
| 12.03.2016 | Harare City | 1-2 | Zanaco FC | |