AS Tanda 2-2 Platinum Stars *
| 16.04.2017 | Platinum Stars | 2-0/p.5-4 | AS Tanda | |
| 09.04.2017 | AS Tanda | 2-0 | Platinum Stars | |
*CF Mounana 2-1 ASEC Mimosas
| 16.04.2017 | ASEC Mimosas | 0-0 | CF Mounana | |
| 08.04.2017 | CF Mounana | 2-1 | ASEC Mimosas | |
Bidvest Wits 0-1 Semouha Club *
| 15.04.2017 | Semouha Club | 1-0 | Bidvest Wits | |
| 08.04.2017 | Bidvest Wits | 0-0 | Semouha Club | |
BYC FC 1-6 SuperSport United *
| 16.04.2017 | SuperSport United | 5-0 | BYC FC | |
| 09.04.2017 | BYC FC | 1-1 | SuperSport United | |
AS Port-Louis 2000 3-6 Club Africain Tunis *
| 15.04.2017 | Club Africain Tunis | 4-2 | AS Port-Louis 2000 | |
| 09.04.2017 | AS Port-Louis 2000 | 1-2 | Club Africain Tunis | |
CNaPS Sport 1-1 Recreativo Libolo *
| 15.04.2017 | Recreativo Libolo | 0-0 | CNaPS Sport | |
| 08.04.2017 | CNaPS Sport | 1-1 | Recreativo Libolo | |
Gambia Ports A. 1-4 Hilal Ubayyid *
| 16.04.2017 | Hilal Ubayyid | 3-0 | Gambia Ports A. | |
| 09.04.2017 | Gambia Ports A. | 1-1 | Hilal Ubayyid | |
*Horoya AC 4-3 Ittihad Tanger
| 15.04.2017 | Ittihad Tanger | 3-2 | Horoya AC | |
| 09.04.2017 | Horoya AC | 2-0 | Ittihad Tanger | |
*FUS Rabat 3-2 Maghreb Fès
| 15.04.2017 | Maghreb Fès | 1-1 | FUS Rabat | |
| 09.04.2017 | FUS Rabat | 2-1 | Maghreb Fès | |
AC Léopard 3-4 Mbabane Swallows *
| 15.04.2017 | Mbabane Swallows | 4-2 | AC Léopard | |
| 09.04.2017 | AC Léopard | 1-0 | Mbabane Swallows | |
Rail Club Kadiogo 1-4 CS Sfaxien *
| 14.04.2017 | CS Sfaxien | 2-0 | Rail Club Kadiogo | |
| 09.04.2017 | Rail Club Kadiogo | 1-2 | CS Sfaxien | |
*Rivers United 2-0 Rayon Sports
| 22.04.2017 | Rayon Sports | 0-0 | Rivers United | |
| 16.04.2017 | Rivers United | 2-0 | Rayon Sports | |
*TP Mazembe 2-0 JS Kabylie
| 16.04.2017 | JS Kabylie | 0-0 | TP Mazembe | |
| 09.04.2017 | TP Mazembe | 2-0 | JS Kabylie | |
Young Africans 1-4 MC Alger *
| 15.04.2017 | MC Alger | 4-0 | Young Africans | |
| 08.04.2017 | Young Africans | 1-0 | MC Alger | |
Enugu Rangers 2-5 ZESCO United *
| 15.04.2017 | ZESCO United | 3-0 | Enugu Rangers | |
| 09.04.2017 | Enugu Rangers | 2-2 | ZESCO United | |