Akanda FC 0-1 FC Renaissance (DRC) *
| 17.02.2017 | FC Renaissance (DRC) | 1-0 | Akanda FC | |
| 10.02.2017 | Akanda FC | 0-0 | FC Renaissance (DRC) | |
*APEJES 2-2 NGB ASC Niarry Tally
| 18.02.2017 | NGB ASC Niarry Tally | 2-1 | APEJES | |
| 12.02.2017 | APEJES | 1-0 | NGB ASC Niarry Tally | |
AS Douanes Niamey 1-3 Ittihad Tanger *
| 19.02.2017 | Ittihad Tanger | 1-0 | AS Douanes Niamey | |
| 11.02.2017 | AS Douanes Niamey | 1-2 | Ittihad Tanger | |
AS Sonabel 0-3 SC Gagnoa *
| 18.02.2017 | SC Gagnoa | 3-0 | AS Sonabel | |
| 12.02.2017 | AS Sonabel | 0-0 | SC Gagnoa | |
Ifeanyi Ubah 1-1 Al Masry *
| 19.02.2017 | Al Masry | 1-0/p.3-0 | Ifeanyi Ubah | |
| 12.02.2017 | Ifeanyi Ubah | 1-0 | Al Masry | |
KVZ FC 2-4 Le Messager Ngozi *
| 18.02.2017 | Le Messager Ngozi | 3-0 | KVZ FC | |
| 12.02.2017 | KVZ FC | 2-1 | Le Messager Ngozi | |
*Maghreb Fès 3-2 CARA Brazzaville
| 18.02.2017 | CARA Brazzaville | 2-0 | Maghreb Fès | |
| 11.02.2017 | Maghreb Fès | 3-0 | CARA Brazzaville | |
Bechem United 3-5 MC Alger
| 18.02.2017 | MC Alger | 4-1 | Bechem United | |
| 12.02.2017 | Bechem United | 2-1 | MC Alger | |
Monrovia Club Breweries 3-4 JS Kabylie *
| 19.02.2017 | JS Kabylie | 4-0 | Monrovia Club Breweries | |
| 10.02.2017 | Monrovia Club Breweries | 3-0 | JS Kabylie | |
Orapa United 2-4 Mbabane Swallows *
| 18.02.2017 | Mbabane Swallows | 3-2 | Orapa United | |
| 11.02.2017 | Orapa United | 0-1 | Mbabane Swallows | |
Pamplemousses 1-2 Ngezi Platinum Stars *
| 18.02.2017 | Ngezi Platinum Stars | 1-0 | Pamplemousses | |
| 12.02.2017 | Pamplemousses | 1-1 | Ngezi Platinum Stars | |
*Platinum Stars 2-0 UD Songo
| 18.02.2017 | UD Songo | 0-1 | Platinum Stars | |
| 11.02.2017 | Platinum Stars | 1-0 | UD Songo | |
*Étoile du Congo 3-0 Racing de Micomeseng
| 19.02.2017 | Racing de Micomeseng | 0-1 | Étoile du Congo | |
| 11.02.2017 | Étoile du Congo | 2-0 | Racing de Micomeseng | |
*RSLAF FC 2-1 Wikki Tourists
| 19.02.2017 | Wikki Tourists | 1-0 | RSLAF FC | |
| 12.02.2017 | RSLAF FC | 2-0 | Wikki Tourists | |
*Hilal Ubayyid 3-0 St Michel United
| 18.02.2017 | St Michel United | 0-1 | Hilal Ubayyid | |
| 10.02.2017 | Hilal Ubayyid | 2-0 | St Michel United | |
ASSM Elgeco Plus 1-2 SuperSport United *
| 19.02.2017 | SuperSport United | 2-1 | ASSM Elgeco Plus | |
| 12.02.2017 | ASSM Elgeco Plus | 0-0 | SuperSport United | |
Hilal Benghazi 1-1 Ulinzi Stars *
| 18.02.2017 | Ulinzi Stars | 1-0/p.5-4 | Hilal Benghazi | |
| 10.02.2017 | Hilal Benghazi | 1-0 | Ulinzi Stars | |
*Vipers SC 1-1 Volcan Club
| 18.02.2017 | Volcan Club | 1-1 | Vipers SC | |
| 11.02.2017 | Vipers SC | 0-0 | Volcan Club | |
Wau Salaam 0-6 Rayon Sports *
| 19.02.2017 | Rayon Sports | 2-0 | Wau Salaam | |
| 11.02.2017 | Wau Salaam | 0-4 | Rayon Sports | |
Defense (ETH) 1-2 Yong Sports Academy *
| 18.02.2017 | Yong Sports Academy | 2-0 | Defense (ETH) | |
| 12.02.2017 | Defense (ETH) | 1-0 | Yong Sports Academy | |