Ahli Shandi 1-1 AS Nyuki *
| 05.12.2018 | AS Nyuki | 1-0/p.4-2 | Ahli Shandi | |
| 28.11.2018 | Ahli Shandi | 1-0 | AS Nyuki | |
*DC Motema Pembe 5-2 Anges de Fatima
| 05.12.2018 | Anges de Fatima | 1-1 | DC Motema Pembe | |
| 28.11.2018 | DC Motema Pembe | 4-1 | Anges de Fatima | |
*Kariobangi Sharks 9-1 AS Arta
| 05.12.2018 | AS Arta | 0-3 | Kariobangi Sharks | |
| 27.11.2018 | Kariobangi Sharks | 6-1 | AS Arta | |
*AS CotonTchad 3-1 Gomido FC
| 05.12.2018 | Gomido FC | 1-1 | AS CotonTchad | |
| 28.11.2018 | AS CotonTchad | 2-0 | Gomido FC | |
*ASSM Elgeco Plus 4-3 Deportivo Unidad
| 05.12.2018 | Deportivo Unidad | 2-1 | ASSM Elgeco Plus | |
| 28.11.2018 | ASSM Elgeco Plus | 3-1 | Deportivo Unidad | |
*NA Hussein Dey 3-1 Diables Noirs
| 04.12.2018 | Diables Noirs | 1-1 | NA Hussein Dey | |
| 27.11.2018 | NA Hussein Dey | 2-0 | Diables Noirs | |
*AS Génération Foot 1-0 Djoliba AC
| 04.12.2018 | Djoliba AC | 0-1 | AS Génération Foot | |
| 28.11.2018 | AS Génération Foot | 0-0 | Djoliba AC | |
*Enugu Rangers 5-1 Defense (ETH)
| 05.12.2018 | Defense (ETH) | 1-3 | Enugu Rangers | |
| 28.11.2018 | Enugu Rangers | 2-0 | Defense (ETH) | |
*FC San Pédro 2-1 Armed Forces FC
| 04.12.2018 | Armed Forces FC | 0-1 | FC San Pédro | |
| 27.11.2018 | FC San Pédro | 1-1 | Armed Forces FC | |
Free State Stars 0-1 Mukura Victory Sports *
| 05.12.2018 | Mukura Victory Sports | 1-0 | Free State Stars | |
| 28.11.2018 | Free State Stars | 0-0 | Mukura Victory Sports | |
*Green Buffaloes 2-0 Al Merreikh Juba
| 05.12.2018 | Al Merreikh Juba | 0-0 | Green Buffaloes | |
| 28.11.2018 | Green Buffaloes | 2-0 | Al Merreikh Juba | |
*Green Eagles 5-2 Young Buffaloes
| 05.12.2018 | Young Buffaloes | 2-3 | Green Eagles | |
| 27.11.2018 | Green Eagles | 2-0 | Young Buffaloes | |
*Hassania Agadir 4-0 AS GNN
| 04.12.2018 | AS GNN | 0-0 | Hassania Agadir | |
| 27.11.2018 | Hassania Agadir | 4-0 | AS GNN | |
*Kaizer Chiefs 5-2 Zimamoto FC
| 04.12.2018 | Zimamoto FC | 2-1 | Kaizer Chiefs | |
| 28.11.2018 | Kaizer Chiefs | 4-0 | Zimamoto FC | |
Miracle Club 0-11 Ittihad Tripoli *
| 05.12.2018 | Ittihad Tripoli | 3-0 W.O. | Miracle Club | |
| 28.11.2018 | Miracle Club | 0-8 | Ittihad Tripoli | |
*Mtibwa Sugar 5-0 Northern Dynamo
| 04.12.2018 | Northern Dynamo | 0-1 | Mtibwa Sugar | |
| 27.11.2018 | Mtibwa Sugar | 4-0 | Northern Dynamo | |
*Petro Atlético Luanda 6-0 Orapa United
| 05.12.2018 | Orapa United | 0-2 | Petro Atlético Luanda | |
| 27.11.2018 | Petro Atlético Luanda | 4-0 | Orapa United | |
*Cercle Mbéri Sportif 1-1 Silver Strikers
| 05.12.2018 | Silver Strikers | 1-0/p.2-3 | Cercle Mbéri Sportif | |
| 28.11.2018 | Cercle Mbéri Sportif | 1-0 | Silver Strikers | |
Nouakchott King's 2-2 Stade d'Abidjan *
| 04.12.2018 | Stade d'Abidjan | 0-1 | Nouakchott King's | |
| 27.11.2018 | Nouakchott King's | 1-2 | Stade d'Abidjan | |
*USM Bel Abbès 4-1 LISCR Monrovia
| 05.12.2018 | LISCR Monrovia | 1-0 | USM Bel Abbès | |
| 27.11.2018 | USM Bel Abbès | 4-0 | LISCR Monrovia | |
*New Stars de Duala 4-1 Vital'O FC
| 05.12.2018 | Vital'O FC | 1-4 | New Stars de Duala | |
| 28.11.2018 | New Stars de Duala | 0-0 | Vital'O FC | |
*Salitas FC 3-3 Wakriya AC
| 04.12.2018 | Wakriya AC | 3-1 | Salitas FC | |
| 27.11.2018 | Salitas FC | 2-0 | Wakriya AC | |