Al Ahli Tripoli 1-1 New Stars de Duala *
| 23.12.2018 | New Stars de Duala | 0-0 | Al Ahli Tripoli | |
| 15.12.2018 | Al Ahli Tripoli | 1-1 | New Stars de Duala | |
*Zamalek SC 7-2 AS CotonTchad
| 23.12.2018 | AS CotonTchad | 2-0 | Zamalek SC | |
| 15.12.2018 | Zamalek SC | 7-0 | AS CotonTchad | |
*Kaizer Chiefs 6-0 ASSM Elgeco Plus
| 22.12.2018 | ASSM Elgeco Plus | 0-3 | Kaizer Chiefs | |
| 15.12.2018 | Kaizer Chiefs | 3-0 | ASSM Elgeco Plus | |
*Raja Casablanca 5-1 Cercle Mbéri Sportif
| 22.12.2018 | Cercle Mbéri Sportif | 1-0 | Raja Casablanca | |
| 16.12.2018 | Raja Casablanca | 5-0 | Cercle Mbéri Sportif | |
*CS Sfaxien 4-2 Green Buffaloes
| 23.12.2018 | Green Buffaloes | 1-0 | CS Sfaxien | |
| 15.12.2018 | CS Sfaxien | 4-1 | Green Buffaloes | |
USM Bel Abbès 0-2 Enugu Rangers *
| 23.12.2018 | Enugu Rangers | 2-0 | USM Bel Abbès | |
| 15.12.2018 | USM Bel Abbès | 0-0 | Enugu Rangers | |
DC Motema Pembe 1-3 FC San Pédro *
| 22.12.2018 | FC San Pédro | 2-0 | DC Motema Pembe | |
| 15.12.2018 | DC Motema Pembe | 1-1 | FC San Pédro | |
Green Eagles 1-2 NA Hussein Dey *
| 22.12.2018 | NA Hussein Dey | 2-1 | Green Eagles | |
| 15.12.2018 | Green Eagles | 0-0 | NA Hussein Dey | |
*Hassania Agadir 2-1 AS Génération Foot
| 23.12.2018 | AS Génération Foot | 1-0 | Hassania Agadir | |
| 14.12.2018 | Hassania Agadir | 2-0 | AS Génération Foot | |
*Renaissance Berkane 4-0 Ittihad Tripoli
| 22.12.2018 | Ittihad Tripoli | 0-1 | Renaissance Berkane | |
| 15.12.2018 | Renaissance Berkane | 3-0 | Ittihad Tripoli | |
Kariobangi Sharks 1-2 Asante Kotoko *
| 22.12.2018 | Asante Kotoko | 2-1 | Kariobangi Sharks | |
| 15.12.2018 | Kariobangi Sharks | 0-0 | Asante Kotoko | |
*KCCA FC 5-1 Mtibwa Sugar
| 22.12.2018 | Mtibwa Sugar | 1-2 | KCCA FC | |
| 15.12.2018 | KCCA FC | 3-0 | Mtibwa Sugar | |
Hilal Ubayyid 0-0 Mukura Victory Sports *
| 22.12.2018 | Mukura Victory Sports | 0-0/p.5-4 | Hilal Ubayyid | |
| 15.12.2018 | Hilal Ubayyid | 0-0 | Mukura Victory Sports | |
AS Nyuki 0-2 Petro Atlético Luanda *
| 21.12.2018 | Petro Atlético Luanda | 1-0 | AS Nyuki | |
| 14.12.2018 | AS Nyuki | 0-1 | Petro Atlético Luanda | |
Al Masry 0-2 Salitas FC *
| 22.12.2018 | Salitas FC | 0-0 | Al Masry | |
| 15.12.2018 | Al Masry | 0-2 | Salitas FC | |
*Étoile Sahel Sousse 3-1 Stade d'Abidjan
| 21.12.2018 | Stade d'Abidjan | 1-0 | Étoile Sahel Sousse | |
| 15.12.2018 | Étoile Sahel Sousse | 3-0 | Stade d'Abidjan | |