*Aduana Stars 7-3 Fosa Juniors
| 18.04.2018 | Fosa Juniors | 2-1 | Aduana Stars | |
| 08.04.2018 | Aduana Stars | 6-1 | Fosa Juniors | |
*Al Hilal Al Sudani 3-3 Akwa United
| 18.04.2018 | Akwa United | 3-1 | Al Hilal Al Sudani | |
| 08.04.2018 | Al Hilal Al Sudani | 2-0 | Akwa United | |
AS Génération Foot 3-3 Renaissance Berkane *
| 18.04.2018 | Renaissance Berkane | 2-0 | AS Génération Foot | |
| 07.04.2018 | AS Génération Foot | 3-1 | Renaissance Berkane | |
*AS Vita Club 6-1 CS La Mancha
| 17.04.2018 | CS La Mancha | 1-5 | AS Vita Club | |
| 07.04.2018 | AS Vita Club | 1-0 | CS La Mancha | |
Bidvest Wits 1-1 Enyimba FC *
| 18.04.2018 | Enyimba FC | 0-0 | Bidvest Wits | |
| 06.04.2018 | Bidvest Wits | 1-1 | Enyimba FC | |
Saint George SA 1-1 CARA Brazzaville *
| 18.04.2018 | CARA Brazzaville | 1-0/p.4-3 | Saint George SA | |
| 07.04.2018 | Saint George SA | 1-0 | CARA Brazzaville | |
CF Mounana 2-3 Al Masry SC *
| 17.04.2018 | Al Masry SC | 2-1 | CF Mounana | |
| 06.04.2018 | CF Mounana | 1-1 | Al Masry SC | |
*Rayon Sports 3-2 Costa do Sol Maputo
| 18.04.2018 | Costa do Sol Maputo | 2-0 | Rayon Sports | |
| 06.04.2018 | Rayon Sports | 3-0 | Costa do Sol Maputo | |
*ASEC Mimosas 1-0 CR Belouizdad
| 17.04.2018 | CR Belouizdad | 0-0 | ASEC Mimosas | |
| 08.04.2018 | ASEC Mimosas | 1-0 | CR Belouizdad | |
*Williamsville AC 3-2 Deportivo Niefang
| 18.04.2018 | Deportivo Niefang | 2-1 | Williamsville AC | |
| 07.04.2018 | Williamsville AC | 2-0 | Deportivo Niefang | |
MFM FC 0-1 Djoliba AC *
| 18.04.2018 | Djoliba AC | 0-0 | MFM FC | |
| 08.04.2018 | MFM FC | 0-1 | Djoliba AC | |
*UD Songo 4-3 Hilal Ubayyid
| 18.04.2018 | Hilal Ubayyid | 2-1 | UD Songo | |
| 07.04.2018 | UD Songo | 3-1 | Hilal Ubayyid | |
Plateau United 2-5 USM Alger *
| 17.04.2018 | USM Alger | 4-0 | Plateau United | |
| 07.04.2018 | Plateau United | 2-1 | USM Alger | |
Zanaco FC 0-5 Raja Casablanca *
| 18.04.2018 | Raja Casablanca | 3-0 | Zanaco FC | |
| 07.04.2018 | Zanaco FC | 0-2 | Raja Casablanca | |
*Gor Mahia 2-2 SuperSport United
| 18.04.2018 | SuperSport United | 2-1 | Gor Mahia | |
| 08.04.2018 | Gor Mahia | 1-0 | SuperSport United | |
*Young Africans 2-1 Wolaitta Dicha
| 18.04.2018 | Wolaitta Dicha | 1-0 | Young Africans | |
| 07.04.2018 | Young Africans | 2-0 | Wolaitta Dicha | |