*Akwa United 3-2 Banjul Hawks
| 21.02.2018 | Banjul Hawks | 0-2 | Akwa United | |
| 11.02.2018 | Akwa United | 1-2 | Banjul Hawks | |
*Al Masry SC 5-2 Green Buffaloes
| 20.02.2018 | Green Buffaloes | 2-1 | Al Masry SC | |
| 10.02.2018 | Al Masry SC | 4-0 | Green Buffaloes | |
*APR FC 6-1 Anse Réunion
| 20.02.2018 | Anse Réunion | 1-2 | APR FC | |
| 11.02.2018 | APR FC | 4-0 | Anse Réunion | |
AS Mangasport 1-2 AS Maniema Union *
| 21.02.2018 | AS Maniema Union | 1-1 | AS Mangasport | |
| 10.02.2018 | AS Mangasport | 0-1 | AS Maniema Union | |
Asante Kotoko 1-1 CARA Brazzaville *
| 21.02.2018 | CARA Brazzaville | 1-0/p.7-6 | Asante Kotoko | |
| 11.02.2018 | Asante Kotoko | 1-0 | CARA Brazzaville | |
*Costa do Sol Maputo 2-0 Jwaneng Galaxy
| 21.02.2018 | Jwaneng Galaxy | 0-1 | Costa do Sol Maputo | |
| 10.02.2018 | Costa do Sol Maputo | 1-0 | Jwaneng Galaxy | |
AS Tanda 0-1 CS La Mancha *
| 20.02.2018 | CS La Mancha | 1-0 | AS Tanda | |
| 10.02.2018 | AS Tanda | 0-0 | CS La Mancha | |
New Stars de Duala 2-2 Deportivo Niefang *
| 20.02.2018 | Deportivo Niefang | 1-0 | New Stars de Duala | |
| 10.02.2018 | New Stars de Duala | 2-1 | Deportivo Niefang | |
*Djoliba AC 6-0 ELWA United
| 20.02.2018 | ELWA United | 0-3 W.O. | Djoliba AC | |
| 09.02.2018 | Djoliba AC | 3-0 W.O. | ELWA United | |
Africa Sports 1-2 FC Nouadhibou *
| 21.02.2018 | FC Nouadhibou | 1-0 | Africa Sports | |
| 11.02.2018 | Africa Sports | 1-1 | FC Nouadhibou | |
AFC Leopards 1-1 Fosa Juniors *
| 21.02.2018 | Fosa Juniors | 0-0 | AFC Leopards | |
| 11.02.2018 | AFC Leopards | 1-1 | Fosa Juniors | |
*Energie FC 2-1 Hafia FC
| 20.02.2018 | Hafia FC | 1-1 | Energie FC | |
| 10.02.2018 | Energie FC | 1-0 | Hafia FC | |
*Petro Atlético Luanda 5-0 Masters Security
| 20.02.2018 | Masters Security | 0-0 | Petro Atlético Luanda | |
| 10.02.2018 | Petro Atlético Luanda | 5-0 | Masters Security | |
Ngazi Sport 2-5 AS Port-Louis 2000 *
| 20.02.2018 | AS Port-Louis 2000 | 4-1 | Ngazi Sport | |
| 10.02.2018 | Ngazi Sport | 1-1 | AS Port-Louis 2000 | |
*Olympique Star 1-0 Étoile Filante
| 21.02.2018 | Étoile Filante | 0-1 | Olympique Star | |
| 10.02.2018 | Olympique Star | 0-0 | Étoile Filante | |
Onze Créateurs 1-3 CR Belouizdad *
| 20.02.2018 | CR Belouizdad | 2-0 | Onze Créateurs | |
| 09.02.2018 | Onze Créateurs | 1-1 | CR Belouizdad | |
*Renaissance Berkane 3-2 Mbour Petite-Côte
| 21.02.2018 | Mbour Petite-Côte | 1-1 | Renaissance Berkane | |
| 11.02.2018 | Renaissance Berkane | 2-1 | Mbour Petite-Côte | |
*Ittihad Tripoli 4-0 Sahel SC Niamey
| 21.02.2018 | Sahel SC Niamey | 0-3 | Ittihad Tripoli | |
| 10.02.2018 | Ittihad Tripoli | 1-0 | Sahel SC Niamey | |
*Simba SC 5-0 Gendarmerie Nationale
| 20.02.2018 | Gendarmerie Nationale | 0-1 | Simba SC | |
| 11.02.2018 | Simba SC | 4-0 | Gendarmerie Nationale | |
*US Ben Guerdane 6-0 Al Hilal Juba
| 20.02.2018 | Al Hilal Juba | 0-3 W.O. | US Ben Guerdane | |
| 10.02.2018 | US Ben Guerdane | 3-0 W.O. | Al Hilal Juba | |
Zimamoto FC 1-2 Wolaitta Dicha *
| 21.02.2018 | Wolaitta Dicha | 1-0 | Zimamoto FC | |
| 11.02.2018 | Zimamoto FC | 1-1 | Wolaitta Dicha | |
Young Buffaloes 0-2 Cape Town City *
| 20.02.2018 | Cape Town City | 1-0 | Young Buffaloes | |
| 10.02.2018 | Young Buffaloes | 0-1 | Cape Town City | |