*US Monastir 2-0 Al Ahli Tripoli
| 06.01.2021 | Al Ahli Tripoli | 0-0 | US Monastir | |
| 23.12.2020 | US Monastir | 2-0 | Al Ahli Tripoli | |
Al Mokawloon Al Arab 1-2 Étoile Sahel Sousse *
| 06.01.2021 | Étoile Sahel Sousse | 2-1 | Al Mokawloon Al Arab | |
| 22.12.2020 | Al Mokawloon Al Arab | 0-0 | Étoile Sahel Sousse | |
Bravos do Maquis 1-3 DC Motema Pembe *
| 05.01.2021 | DC Motema Pembe | 2-1 | Bravos do Maquis | |
| 23.12.2020 | Bravos do Maquis | 0-1 | DC Motema Pembe | |
*TAS Casablanca 5-1 ESAE FC
| 06.01.2021 | ESAE FC | 1-1 | TAS Casablanca | |
| 23.12.2020 | TAS Casablanca | 4-0 | ESAE FC | |
*ASC Jaraaf 2-2 FC San Pédro
| 06.01.2021 | FC San Pédro | 1-2 | ASC Jaraaf | |
| 23.12.2020 | ASC Jaraaf | 0-1 | FC San Pédro | |
FC Tevragh-Zeina 0-2 Renaissance Berkane *
| 06.01.2021 | Renaissance Berkane | 2-0 | FC Tevragh-Zeina | |
| 23.12.2020 | FC Tevragh-Zeina | 0-0 | Renaissance Berkane | |
Green Eagles 0-3 Coton Sport *
| 05.01.2021 | Coton Sport | 1-0 | Green Eagles | |
| 23.12.2020 | Green Eagles | 0-2 | Coton Sport | |
*Namungo FC 5-3 Hilal Ubayyid
| 05.01.2021 | Hilal Ubayyid | 3-3 | Namungo FC | |
| 23.12.2020 | Namungo FC | 2-0 | Hilal Ubayyid | |
Ittihad Tripoli 2-4 Pyramids FC *
| 05.01.2021 | Pyramids FC | 3-2 | Ittihad Tripoli | |
| 22.12.2020 | Ittihad Tripoli | 0-1 | Pyramids FC | |
US GN 1-4 JS Kabylie *
| 05.01.2021 | JS Kabylie | 2-0 | US GN | |
| 22.12.2020 | US GN | 1-2 | JS Kabylie | |
Sagrada Esperanca 0-3 Orlando Pirates *
| 06.01.2021 | Orlando Pirates | 2-0 W.O. | Sagrada Esperanca | |
| 22.12.2020 | Sagrada Esperanca | 0-1 | Orlando Pirates | |
Renaissance (CHA) 0-4 ES Sétif *
| 05.01.2021 | ES Sétif | 2-0 W.O. | Renaissance (CHA) | |
| 23.12.2020 | Renaissance (CHA) | 0-2 W.O. | ES Sétif | |
Bloemfontein Celtic 0-5 Rivers United *
| 23.01.2021 | Rivers United | 3-0 | Bloemfontein Celtic | |
| 23.12.2020 | Bloemfontein Celtic | 0-2 | Rivers United | |
Al Amal Atbara 0-3 Salitas FC *
| 06.01.2021 | Salitas FC | 2-0 | Al Amal Atbara | |
| 22.12.2020 | Al Amal Atbara | 0-1 | Salitas FC | |
*Napsa Stars 1-1 UD Songo
| 06.01.2021 | UD Songo | 1-1 | Napsa Stars | |
| 22.12.2020 | Napsa Stars | 0-0 | UD Songo | |