Al Masry 2-2 Renaissance Berkane *
| 25.04.2022 | Renaissance Berkane | 1-0 | Al Masry | |
| 17.04.2022 | Al Masry | 2-1 | Renaissance Berkane | |
Ittihad Tripoli 0-1 Al Ahli Tripoli *
| 24.04.2022 | Al Ahli Tripoli | 1-0 | Ittihad Tripoli | |
| 17.04.2022 | Ittihad Tripoli | 0-0 | Al Ahli Tripoli | |
Pyramids FC 0-2 TP Mazembe *
| 24.04.2022 | TP Mazembe | 2-0 | Pyramids FC | |
| 17.04.2022 | Pyramids FC | 0-0 | TP Mazembe | |
Simba SC 1-1 Orlando Pirates *
| 24.04.2022 | Orlando Pirates | 1-0/p.4-3 | Simba SC | |
| 17.04.2022 | Simba SC | 1-0 | Orlando Pirates | |