Al Ahli Tripoli 1-2 Orlando Pirates *
| 15.05.2022 | Orlando Pirates | 0-1 | Al Ahli Tripoli | |
| 08.05.2022 | Al Ahli Tripoli | 0-2 | Orlando Pirates | |
TP Mazembe 2-4 Renaissance Berkane *
| 15.05.2022 | Renaissance Berkane | 4-1 | TP Mazembe | |
| 08.05.2022 | TP Mazembe | 1-0 | Renaissance Berkane | |